Breast Cancer Res Treat (2018) 168:241–248 https://doi.org/10.1007/s10549-017-4573-1 BRIEF REPORT Body mass index, diet, and exercise: testing possible linkages to breast cancer risk via DNA methylation 1 1 1 1 Arielle S. Gillman · Casey K. Gardiner · Claire E. Koljack · Angela D. Bryan Received: 26 July 2017 / Accepted: 6 November 2017 / Published online: 10 November 2017 © Springer Science+Business Media, LLC, part of Springer Nature 2017 Abstract Introduction Purpose To examine DNA methylation as a mechanism linking diet, physical activity, weight status, and breast can- Obesity and breast cancer are high-priority public health cer risk. issues in the United States. More than 1 in 3 adults in the Methods Insufficiently active women of varying weight US are obese, and about 1 in 8 women will be diagnosed status, without a history of cancer, completed a maximal with breast cancer in their lifetime [1, 2]. Importantly, exercise test, clinical measurement of height and weight, and these two public health issues are strongly interrelated. In a dietary intake measure. They also provided blood samples, a recent position statement, the American Society of Clini- which were analyzed to ascertain average methylation of cal Oncology named obesity as a major unrecognized risk candidate genes related to breast cancer (BRCA1, RUNX3,
Breast Cancer Research and Treatment – Springer Journals
Published: Nov 10, 2017
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