Eur J Trauma Emerg Surg (2017) 43:783–789 DOI 10.1007/s00068-017-0779-5 ORIGINAL ARTICLE β-Blocker after severe traumatic brain injury is associated with better long-term functional outcome: a matched case control study 1,3 4 2 4 1 5 R. Ahl · E. P. Thelin · G. Sjölin · B.-M. Bellander · L. Riddez · P. Talving · 1,2,3 S. Mohseni Received: 7 December 2016 / Accepted: 21 February 2017 / Published online: 8 March 2017 © The Author(s) 2017. This article is published with open access at Springerlink.com Abstract Results 362 patients met the inclusion criteria with 21% Purpose Severe traumatic brain injury (TBI) is the pre- receiving β-blockers during admission. After propen- dominant cause of death and disability following trauma. sity matching, 76 matched pairs were available for analy- Several studies have observed improved survival in TBI sis. There were no statistical differences in any variables patients exposed to β-blockers, however, the effect on func- included in the analysis. Mean hospital length of stay was tional outcome is poorly documented. shorter in the β-blocked cases (18.0 vs. 26.8 days, p < 0.01). Methods Adult patients with severe TBI (head AIS ≥ 3) The risk of poor long-term functional outcome was more were identified from a prospectively collected TBI data- than doubled in
European Journal of Trauma and Emergency Surgery – Springer Journals
Published: Mar 8, 2017
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