Graefes Arch Clin Exp Ophthalmol (2017) 255:1573–1579 DOI 10.1007/s00417-017-3651-8 BASIC SCIENCE Blockade of MMP-2 and MMP-9 inhibits corneal lymphangiogenesis 1 1 1 1 1 Hai-Tao Du & Ling-Ling Du & Xian-Ling Tang & Hong-Yan Ge & Ping Liu Received: 21 November 2016 /Revised: 13 February 2017 /Accepted: 20 March 2017 /Published online: 1 July 2017 Springer-Verlag Berlin Heidelberg 2017 . . . Abstract Keywords MMP-2 MMP-9 VEGF-C Purpose To investigate the roles of a selective MMP-2 Lymphangiogenesis Cornea inflammation and -9 inhibitor (SB-3CT) in corneal inflammatory lymphangiogenesis. Methods The expression of MMP-2 and -9 in the cornea after Introduction suture inplacement, treated with SB-3CT or negative control, was detected by real-time polymerase chain reaction (PCR). Lymphatic vessels are critical to organ and tissue mainte- Inflammatory corneal neovascularization (NV) was induced nance. The lymphatic networks play an important role in the by corneal suture placement. Mice were treated with SB-3CT regulation of tissue fluid homeostasis and the return of mac- eye drops (twice daily for 1 week, 5 μL per drop; 50, 100, or romolecules and immune cells to the bloodstream [1, 2]. In its 200 μM). The outgrowth of blood and lymphatic vessels, and normal state, the cornea is
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Jul 1, 2017
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