Blind method regarding the effect of dexmedetomidine on CRBD

Blind method regarding the effect of dexmedetomidine on CRBD Journal of Anesthesia (2018) 32:461 https://doi.org/10.1007/s00540-018-2497-5 LE T TER TO  THE   EDITOR 1 2 1 Bailong Hu  · Haiyan Zhou  · Xiaohua Zou Received: 19 February 2018 / Accepted: 12 April 2018 / Published online: 26 April 2018 © Japanese Society of Anesthesiologists 2018 To the Editor: normal saline 2 mL) should be diluted into the same syringe with normal saline to 50 mL, and infused at a loading rate of We have read an article written by Kwon et al. with great 0.25 mL/kg over 10 min, followed by a continuous infusion interest [1]. It is a welcome investigation which evaluated of 0.075–0.125 mL/kg/h according to the study of Su et al the effect of the intraoperative dexmedetomidine (DEX) on [2], but not at the dose of DEX (µg/kg/h), so that the opera- the incidence and severity of catheter-related bladder dis- tor is blinded to the group allocation. comfort (CRBD) after nonurologic surgery. We agree with their conclusion that DEX may have benefits in preventing Compliance with Ethical Standards CRBD after lumbar microdiscectomy. However, we have a Conflict of interest None declared. question regarding the blind method. In this article, the author stated that DEX was infused at a loading dose of 1 µg/kg over 10 min, followed by a References continuous infusion of 0.3–0.5 µg/ kg/h, the dose of which is adjusted by the operator based on blood pressure, heart 1. Kwon Y, Jang JS, Hwang SM, Lee JJ, Tark H. Intraoperative rate, and BIS values in group D (experimental group), while administration of dexmedetomidine reduced the postoperative an identical volume of 0.9% saline was infused in the same catheter-related bladder discomfort and pain in patients undergo- manner in the group C (control group). According to the ing lumbar microdiscectomy[J]. Journal Anesth. 2017:1–7. 2. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, author’s description, the operator was aware of both groups Zhu SN, Maze M, Ma D. Dexmedetomidine for prevention of for each individual. In other words, the operator was not delirium in elderly patients after non-cardiac surgery: a ran- blinded, which may cause the possibility of observation bias. domised, double-blind, placebo-controlled trial[J]. Lancet. We suggest that the study drugs (DEX 200 µg/2 mL and 2016;388(10054):1893–902. Bailong Hu, Haiyan Zhou and Xiaohua Zou contributed equally to the letter. This comment refers to the article available at: https ://doi. org/10.1007/s0054 0-017-2425-0. * Bailong Hu 375896605@qq.com Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004 Guiyang, China Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004 Guiyang, China Vol.:(0123456789) 1 3 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Anesthesia Springer Journals

Blind method regarding the effect of dexmedetomidine on CRBD

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Publisher
Springer Japan
Copyright
Copyright © 2018 by Japanese Society of Anesthesiologists
Subject
Medicine & Public Health; Anesthesiology; Pain Medicine; Intensive / Critical Care Medicine; Emergency Medicine
ISSN
0913-8668
eISSN
1438-8359
D.O.I.
10.1007/s00540-018-2497-5
Publisher site
See Article on Publisher Site

Abstract

Journal of Anesthesia (2018) 32:461 https://doi.org/10.1007/s00540-018-2497-5 LE T TER TO  THE   EDITOR 1 2 1 Bailong Hu  · Haiyan Zhou  · Xiaohua Zou Received: 19 February 2018 / Accepted: 12 April 2018 / Published online: 26 April 2018 © Japanese Society of Anesthesiologists 2018 To the Editor: normal saline 2 mL) should be diluted into the same syringe with normal saline to 50 mL, and infused at a loading rate of We have read an article written by Kwon et al. with great 0.25 mL/kg over 10 min, followed by a continuous infusion interest [1]. It is a welcome investigation which evaluated of 0.075–0.125 mL/kg/h according to the study of Su et al the effect of the intraoperative dexmedetomidine (DEX) on [2], but not at the dose of DEX (µg/kg/h), so that the opera- the incidence and severity of catheter-related bladder dis- tor is blinded to the group allocation. comfort (CRBD) after nonurologic surgery. We agree with their conclusion that DEX may have benefits in preventing Compliance with Ethical Standards CRBD after lumbar microdiscectomy. However, we have a Conflict of interest None declared. question regarding the blind method. In this article, the author stated that DEX was infused at a loading dose of 1 µg/kg over 10 min, followed by a References continuous infusion of 0.3–0.5 µg/ kg/h, the dose of which is adjusted by the operator based on blood pressure, heart 1. Kwon Y, Jang JS, Hwang SM, Lee JJ, Tark H. Intraoperative rate, and BIS values in group D (experimental group), while administration of dexmedetomidine reduced the postoperative an identical volume of 0.9% saline was infused in the same catheter-related bladder discomfort and pain in patients undergo- manner in the group C (control group). According to the ing lumbar microdiscectomy[J]. Journal Anesth. 2017:1–7. 2. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, author’s description, the operator was aware of both groups Zhu SN, Maze M, Ma D. Dexmedetomidine for prevention of for each individual. In other words, the operator was not delirium in elderly patients after non-cardiac surgery: a ran- blinded, which may cause the possibility of observation bias. domised, double-blind, placebo-controlled trial[J]. Lancet. We suggest that the study drugs (DEX 200 µg/2 mL and 2016;388(10054):1893–902. Bailong Hu, Haiyan Zhou and Xiaohua Zou contributed equally to the letter. This comment refers to the article available at: https ://doi. org/10.1007/s0054 0-017-2425-0. * Bailong Hu 375896605@qq.com Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004 Guiyang, China Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004 Guiyang, China Vol.:(0123456789) 1 3

Journal

Journal of AnesthesiaSpringer Journals

Published: Apr 26, 2018

References

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