Ann Hematol (2017) 96:1769–1770 DOI 10.1007/s00277-017-3079-6 LETTER TO THE EDITOR Blastic plasmacytoid dendritic cell neoplasm: a pathological illustration of two clinical cases 1 2 3 4 2,5 Jessica C. Griffin & Nayef Aqel & Wenchee Siow & Marquita Camilleri & Robert Ayto Received: 10 June 2017 /Accepted: 23 July 2017 /Published online: 1 August 2017 Springer-Verlag GmbH Germany 2017 Dear Editor, and negative for CD34, CD117, MPO and CD33, compatible Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a with BPDCN (Fig. 1, d2). Infiltrative cells on lymph node rare aggressive disease characterised by clonal proliferation of biopsy were positive for CD4, CD56 and CD123. plasmacytoid dendritic cell precursors . Defined as a mye- The patient commenced FLAG-IDA chemotherapy achiev- ing haematological and radiological complete remission post loid malignancy by the World Health Organisation , it has distinct morphological and immunophenotypic features. We cycle 1. He relapsed rapidly post a second cycle of FLAG- present two cases of BPDCN, with a visual illustration of the IDA in the short assessment period prior to reduced intensity pathological characteristics. allogenic bone marrow transplant. He failed salvage with A 69-year-old male presented with 2 months history of high-dose methotrexate and died from sepsis
Annals of Hematology – Springer Journals
Published: Aug 1, 2017
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