Eur J Nutr (2018) 57:405–415 https://doi.org/10.1007/s00394-017-1506-z ORIGINAL CONTRIBUTION Blackcurrant anthocyanins stimulated cholesterol transport via post‑transcriptional induction of LDL receptor in Caco‑2 cells 1 1 1 2 2 Bohkyung Kim · Minkyung Bae · Young‑Ki Park · Hang Ma · Tao Yuan · 2 1 Navindra P. Seeram · Ji‑Young Lee Received: 7 August 2016 / Accepted: 7 July 2017 / Published online: 17 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract In addition, BCE altered genes involved in cholesterol trans- Purposes We previously showed that polyphenol-rich port in the enterocytes, including apical and basolateral blackcurrant extract (BCE) showed a hypocholesterolemic cholesterol transporters, in such a way that could enhance effect in mice fed a high fat diet. As direct cholesterol cholesterol flux from the basolateral to apical side of the removal from the body via the intestine has been recently enterocytes. Indeed, BCE significantly increased the flux of appreciated, we investigated the effect of BCE on the modu - LDL-derived cholesterol from the basolateral to the apical lation of genes involved in intestinal cholesterol transport chamber of Caco-2 monolayer. LDLR protein levels were using Caco-2 cells as an in vitro model. markedly increased by anthocyanin-rich fraction, but not by Methods Caco-2 cells were treated with BCE to deter- anthocyanin-free fraction.
European Journal of Nutrition – Springer Journals
Published: Jul 17, 2017
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