Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells

Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of... Eur J Nutr (2018) 57:405–415 https://doi.org/10.1007/s00394-017-1506-z ORIGINAL CONTRIBUTION Blackcurrant anthocyanins stimulated cholesterol transport via post‑transcriptional induction of LDL receptor in Caco‑2 cells 1 1 1 2 2 Bohkyung Kim  · Minkyung Bae  · Young‑Ki Park  · Hang Ma  · Tao Yuan  · 2 1 Navindra P. Seeram  · Ji‑Young Lee   Received: 7 August 2016 / Accepted: 7 July 2017 / Published online: 17 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract In addition, BCE altered genes involved in cholesterol trans- Purposes We previously showed that polyphenol-rich port in the enterocytes, including apical and basolateral blackcurrant extract (BCE) showed a hypocholesterolemic cholesterol transporters, in such a way that could enhance effect in mice fed a high fat diet. As direct cholesterol cholesterol flux from the basolateral to apical side of the removal from the body via the intestine has been recently enterocytes. Indeed, BCE significantly increased the flux of appreciated, we investigated the effect of BCE on the modu - LDL-derived cholesterol from the basolateral to the apical lation of genes involved in intestinal cholesterol transport chamber of Caco-2 monolayer. LDLR protein levels were using Caco-2 cells as an in vitro model. markedly increased by anthocyanin-rich fraction, but not by Methods Caco-2 cells were treated with BCE to deter- anthocyanin-free fraction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nutrition Springer Journals

Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Chemistry; Nutrition
ISSN
1436-6207
eISSN
1436-6215
D.O.I.
10.1007/s00394-017-1506-z
Publisher site
See Article on Publisher Site

Abstract

Eur J Nutr (2018) 57:405–415 https://doi.org/10.1007/s00394-017-1506-z ORIGINAL CONTRIBUTION Blackcurrant anthocyanins stimulated cholesterol transport via post‑transcriptional induction of LDL receptor in Caco‑2 cells 1 1 1 2 2 Bohkyung Kim  · Minkyung Bae  · Young‑Ki Park  · Hang Ma  · Tao Yuan  · 2 1 Navindra P. Seeram  · Ji‑Young Lee   Received: 7 August 2016 / Accepted: 7 July 2017 / Published online: 17 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract In addition, BCE altered genes involved in cholesterol trans- Purposes We previously showed that polyphenol-rich port in the enterocytes, including apical and basolateral blackcurrant extract (BCE) showed a hypocholesterolemic cholesterol transporters, in such a way that could enhance effect in mice fed a high fat diet. As direct cholesterol cholesterol flux from the basolateral to apical side of the removal from the body via the intestine has been recently enterocytes. Indeed, BCE significantly increased the flux of appreciated, we investigated the effect of BCE on the modu - LDL-derived cholesterol from the basolateral to the apical lation of genes involved in intestinal cholesterol transport chamber of Caco-2 monolayer. LDLR protein levels were using Caco-2 cells as an in vitro model. markedly increased by anthocyanin-rich fraction, but not by Methods Caco-2 cells were treated with BCE to deter- anthocyanin-free fraction.

Journal

European Journal of NutritionSpringer Journals

Published: Jul 17, 2017

References

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