Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case–control study

Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested... Aims The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). Methods A nested case–control study was performed among Chinese who participated in the environment, inflammation and metabolic diseases study (2008–2013). Of the 3510 subjects who were free of diabetes, 232 subjects developed diabetes during the 5-year follow-up. Cases and controls were matched for age and gender by a ratio of 1:1. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Participants were stratified into tertiles based on low, median and high baseline serum BPA levels. Regression models were used to analyze the relationship between serum BPA concentration and the incidence of T2D. Results At baseline, no significant difference in serum BPA concentration was observed between patients with T2D and controls [1.3 (0.3, 3.7) vs. 1.6 (0.4, 3.9) μmol/L, P = 0.199]; serum BPA concentration was positively associated with fasting plasma glucose (r = 0.27, P < 0.001); however, neither HOMA-β nor HOMA-IR correlated with serum BPA concentra- tion. During the follow-up, baseline BPA levels could not predict the 5-year T2D incidence, whether or not adjusted for the potential confounders such http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Diabetologica Springer Journals

Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case–control study

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag Italia S.r.l., part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; Diabetes; Metabolic Diseases
ISSN
0940-5429
eISSN
1432-5233
D.O.I.
10.1007/s00592-018-1104-4
Publisher site
See Article on Publisher Site

Abstract

Aims The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). Methods A nested case–control study was performed among Chinese who participated in the environment, inflammation and metabolic diseases study (2008–2013). Of the 3510 subjects who were free of diabetes, 232 subjects developed diabetes during the 5-year follow-up. Cases and controls were matched for age and gender by a ratio of 1:1. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Participants were stratified into tertiles based on low, median and high baseline serum BPA levels. Regression models were used to analyze the relationship between serum BPA concentration and the incidence of T2D. Results At baseline, no significant difference in serum BPA concentration was observed between patients with T2D and controls [1.3 (0.3, 3.7) vs. 1.6 (0.4, 3.9) μmol/L, P = 0.199]; serum BPA concentration was positively associated with fasting plasma glucose (r = 0.27, P < 0.001); however, neither HOMA-β nor HOMA-IR correlated with serum BPA concentra- tion. During the follow-up, baseline BPA levels could not predict the 5-year T2D incidence, whether or not adjusted for the potential confounders such

Journal

Acta DiabetologicaSpringer Journals

Published: Jan 31, 2018

References

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