Clin Res Cardiol (2017) 106:711–721 DOI 10.1007/s00392-017-1115-0 ORIGINAL PAPER Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure 1 1 1 1 • • • • Hanna Fro ¨ hlich Lorella Torres Tobias Ta ¨ ger Dieter Schellberg 1 2 9 3 • • • • Anna Corletto Syed Kazmi Kevin Goode Morten Grundtvig 4,5 1 6,7 8 • • • • Torstein Hole Hugo A. Katus John G. F. Cleland Dan Atar 2 8 1 • • Andrew L. Clark Stefan Agewall Lutz Frankenstein Received: 24 January 2017 / Accepted: 11 April 2017 / Published online: 22 April 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract years, 302 (29.5%), 637 (37.0%), and 1232 (37.7%) Aims Beta-blockers are recommended for the treatment of patients died amongst those prescribed bisoprolol, carve- chronic heart failure (CHF). However, it is disputed whe- dilol, and metoprolol, respectively. In univariable analysis ther beta-blockers exert a class effect or whether there are of the general sample, bisoprolol and carvedilol were both differences in efﬁcacy between agents. associated with lower mortality as compared with meto- Methods and results 6010 out-patients with stable CHF prolol succinate (HR 0.80, 95% CI 0.71–0.91, p
Zeitschrift für Kardiologie – Springer Journals
Published: Apr 22, 2017
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