Biosafety Evaluation of Three Sodium Lauryl N-Amino Acids Synthesized from Silk Industrial Waste in Mice

Biosafety Evaluation of Three Sodium Lauryl N-Amino Acids Synthesized from Silk Industrial Waste... In this study, three amino acid mixtures recovered from silk industry waste were reacted with lauryl chloride to synthesize three sodium laurel N-amino acid surfactants. The three types of anionic surfactants are referred to as silk fibroin surfactant, silk sericin surfactant, and silkworm pupae surfactant. All three surfactants showed good surface properties. To evaluate biological safety, we added these three surfactants to the normal diet of mice for 8 weeks. Blood indices, blood lipid, antioxidant capacity (GSH-PX, MDA, T-AOC, and T-SOD), and lipid metabolism key enzyme mRNA (PPAR-γ, SREBP, FASN, and C/EBP-α) levels in the liver were measured. No evident histopathological changes were found in the liver and kidney. The results showed no significant difference in their indexes between the surfactant-fed and normal diet-fed mice. Thus, the three amino acid surfactants are biologically safe and can be used in daily chemical cleaning products. These surfactants will not only help to reduce wastage of resources and damage to the environment, but also yield economic benefits to the silk industry in the future. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surfactants and Detergents Springer Journals

Biosafety Evaluation of Three Sodium Lauryl N-Amino Acids Synthesized from Silk Industrial Waste in Mice

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by AOCS
Subject
Chemistry; Industrial Chemistry/Chemical Engineering; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution; Surfaces and Interfaces, Thin Films; Polymer Sciences; Physical Chemistry
ISSN
1097-3958
eISSN
1558-9293
D.O.I.
10.1007/s11743-017-1995-z
Publisher site
See Article on Publisher Site

Abstract

In this study, three amino acid mixtures recovered from silk industry waste were reacted with lauryl chloride to synthesize three sodium laurel N-amino acid surfactants. The three types of anionic surfactants are referred to as silk fibroin surfactant, silk sericin surfactant, and silkworm pupae surfactant. All three surfactants showed good surface properties. To evaluate biological safety, we added these three surfactants to the normal diet of mice for 8 weeks. Blood indices, blood lipid, antioxidant capacity (GSH-PX, MDA, T-AOC, and T-SOD), and lipid metabolism key enzyme mRNA (PPAR-γ, SREBP, FASN, and C/EBP-α) levels in the liver were measured. No evident histopathological changes were found in the liver and kidney. The results showed no significant difference in their indexes between the surfactant-fed and normal diet-fed mice. Thus, the three amino acid surfactants are biologically safe and can be used in daily chemical cleaning products. These surfactants will not only help to reduce wastage of resources and damage to the environment, but also yield economic benefits to the silk industry in the future.

Journal

Journal of Surfactants and DetergentsSpringer Journals

Published: Jul 14, 2017

References

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