Biomarkers of respiratory allergy in laboratory animal care workers: an observational study

Biomarkers of respiratory allergy in laboratory animal care workers: an observational study Objectives Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers. Methods All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO ), exhaled breath condensate hydrogen peroxide (EBC H O ) and serum 50 2 2 pneumoprotein levels were measured. Multivariate analysis (ANCOVA) was used to assess the interactions of the variables. Results FeNO levels correlated with exposure (p = 0.002), sensitisation (p = 0.000) and age (p = 0.001), but there was no interaction between exposure and sensitisation when age was considered in the model (p = 0.146). EBC-H O levels were 2 2 higher in the sensitised workers than in the sensitised controls [0.14 (0.08–0.29) µM vs 0.07 (0.05–0.12) µM; p < 0.05]. Serum surfactant protein A (SP-A) levels were unaffected by exposure, sensitisation or age, although higher levels were observed in symptomatic workers; however, SP-D levels were influenced by exposure (p = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Archives of Occupational and Environmental Health Springer Journals
Loading next page...
 
/lp/springer_journal/biomarkers-of-respiratory-allergy-in-laboratory-animal-care-workers-an-oL0wCVSYeg
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Environment; Environmental Health; Rehabilitation; Occupational Medicine/Industrial Medicine
ISSN
0340-0131
eISSN
1432-1246
D.O.I.
10.1007/s00420-018-1321-8
Publisher site
See Article on Publisher Site

Abstract

Objectives Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers. Methods All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO ), exhaled breath condensate hydrogen peroxide (EBC H O ) and serum 50 2 2 pneumoprotein levels were measured. Multivariate analysis (ANCOVA) was used to assess the interactions of the variables. Results FeNO levels correlated with exposure (p = 0.002), sensitisation (p = 0.000) and age (p = 0.001), but there was no interaction between exposure and sensitisation when age was considered in the model (p = 0.146). EBC-H O levels were 2 2 higher in the sensitised workers than in the sensitised controls [0.14 (0.08–0.29) µM vs 0.07 (0.05–0.12) µM; p < 0.05]. Serum surfactant protein A (SP-A) levels were unaffected by exposure, sensitisation or age, although higher levels were observed in symptomatic workers; however, SP-D levels were influenced by exposure (p =

Journal

International Archives of Occupational and Environmental HealthSpringer Journals

Published: Jun 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off