Objectives Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers. Methods All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO ), exhaled breath condensate hydrogen peroxide (EBC H O ) and serum 50 2 2 pneumoprotein levels were measured. Multivariate analysis (ANCOVA) was used to assess the interactions of the variables. Results FeNO levels correlated with exposure (p = 0.002), sensitisation (p = 0.000) and age (p = 0.001), but there was no interaction between exposure and sensitisation when age was considered in the model (p = 0.146). EBC-H O levels were 2 2 higher in the sensitised workers than in the sensitised controls [0.14 (0.08–0.29) µM vs 0.07 (0.05–0.12) µM; p < 0.05]. Serum surfactant protein A (SP-A) levels were unaffected by exposure, sensitisation or age, although higher levels were observed in symptomatic workers; however, SP-D levels were influenced by exposure (p =
International Archives of Occupational and Environmental Health – Springer Journals
Published: Jun 1, 2018
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