Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot

Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus... Influenza A virus, A/Eurasian coot/Western Australia/2727/79 (H6N2), from an apparently healthy coot was characterized. This virus was able to grow on MDCK cells and produce a cytopathic effect in the absence of exogenous trypsin and was further characterized as a low-pathogenicity avian influenza virus, with an intravenous pathogenicity index of 0.15 and a 321 PQAETRG 328 motif at the cleavage site of the haemagglutinin gene. It infected domestic chickens, resulting in seroconversion and intermittent virus excretion via cloaca and oropharynx under experimental conditions. Phylogenetic analysis showed that the viral genes were closely related to other waterfowl isolates from the same geographic area and time period. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Biological and genetic characterization of a low-pathogenicity avian influenza H6N2 virus originating from a healthy Eurasian coot

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Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-010-0588-1
Publisher site
See Article on Publisher Site

Abstract

Influenza A virus, A/Eurasian coot/Western Australia/2727/79 (H6N2), from an apparently healthy coot was characterized. This virus was able to grow on MDCK cells and produce a cytopathic effect in the absence of exogenous trypsin and was further characterized as a low-pathogenicity avian influenza virus, with an intravenous pathogenicity index of 0.15 and a 321 PQAETRG 328 motif at the cleavage site of the haemagglutinin gene. It infected domestic chickens, resulting in seroconversion and intermittent virus excretion via cloaca and oropharynx under experimental conditions. Phylogenetic analysis showed that the viral genes were closely related to other waterfowl isolates from the same geographic area and time period.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2010

References

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