Access the full text.
Sign up today, get DeepDyve free for 14 days.
(2009)
Synthesis and study of cytotoxic potency of novel coumarin derivatives agent breast cancer cell line
A. Abu‐Hashem, M. Youssef, H. Hussein (2011)
Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines DerivativesJournal of The Chinese Chemical Society, 58
I. Kempen, D. Papapostolou, N. Thierry, L. Pochet, Stéphane Counerotte, B. Masereel, J. Foidart, M. Reboud-Ravaux, A. Noël, B. Pirotte (2003)
3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivoBritish Journal of Cancer, 88
Thomas Kipping, H. Rein (2012)
Development of Extruded Starch Based FormulationsAimed for Local Drug Delivery to Oral Cavity, 2012
I. Kostova (2005)
Synthetic and natural coumarins as cytotoxic agents.Current medicinal chemistry. Anti-cancer agents, 5 1
M. Humayun, N. Parvez, Y. Sultana, Asgar Ali (2007)
RELEASE KINETICS OF MODIFIED PHARMACEUTICAL DOSAGE FORMS: A REVIEW.
O. Safarjalani, Xiao-jian Zhou, R. Rais, Junxing Shi, R. Schinazi, F. Naguib, M. Kouni (2005)
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimensCancer Chemotherapy and Pharmacology, 55
Neeraj Kumar, Mahesh Chaubal, A. Domb, R. Majeti (2002)
Controlled Release Technology
T. Higuchi (1963)
MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.Journal of pharmaceutical sciences, 52
Raghav Mishra, Isha Tomar (2011)
Pyrimidine: The Molecule of Diverse Biological and Medicinal ImportanceChemInform, 42
O. Safarjalani, R. Rais, Junxing Shi, R. Schinazi, F. Naguib, M. Kouni (2006)
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitorCancer Chemotherapy and Pharmacology, 58
F. Helaly, D. Nashar, A. Khalaf (2009)
Controlling the release of active iron and manganese ions from styrene‐butadiene rubber‐binding matrix containing chloride salts of themJournal of Applied Polymer Science, 113
Z. Nofal, M. El-Zahar, S. El-Karim (2000)
Novel Coumarin Derivatives with Expected Biological ActivityMolecules, 5
S. Nagappa, S. Shivaji (2011)
Design, Synthesis, Docking and Anti-mycobacterial activity of some novel thiouracil derivatives as thymidine monophoshate kinase (TMPKmt) inhibitors
T. Higuchi (1961)
Rate of release of medicaments from ointment bases containing drugs in suspension.Journal of pharmaceutical sciences, 50
(2012)
Formulation and evaluation of matrix-based sustained release tablets of quetiapine fumarate and the influence of excipients on drug release
C. Pereira, António Cunha, R. Reis, Blanca Vázquez, J. Román (1998)
New starch-based thermoplastic hydrogels for use as bone cements or drug-delivery carriersJournal of Materials Science: Materials in Medicine, 9
M. Masoud, A. Ibrahim, E. Khalil, Adel El-marghany (2007)
Spectral properties of some metal complexes derived from uracil-thiouracil and citrazinic acid compounds.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 67 3-4
Supaluk Prachayasittikul, Nirun Sornsongkhram, R. Pingaew, Supin Techatanachai, S. Ruchirawat, V. Prachayasittikul (2009)
Synthesis and Novel Bioactivities of Substituted 6-Propylthiouracils
H. Gad, A. Maghraby (2000)
Synthesis of some new-uracil-5- sulphonamide-p- phenyl derivatives and their effect on Biomphalaria alexandrina snails nucleoproteins
He-ping Li, Long Qin, Zhou-dong Wang, Shanqi Li (2012)
Synthesis and characterization of ramose tetralactosyl-lysyl-chitosan-5-fluorouracil and its in vitro releaseResearch on Chemical Intermediates, 38
Shiuan Chen, Michael Cho, K. Karlsberg, Dujin Zhou, Yate-Ching Yuan (2004)
Biochemical and Biological Characterization of a Novel Anti-aromatase Coumarin Derivative*Journal of Biological Chemistry, 279
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. Mcmahon, D. Vistica, Jonathan Warren, H. Bokesch, S. Kenney, M. Boyd (1990)
New colorimetric cytotoxicity assay for anticancer-drug screening.Journal of the National Cancer Institute, 82 13
O. Fathalla, Wafaa Zaghary, H. Radwan, S. Awad, M. Mohamed (2002)
Synthesis of new 2-thiouracil-5-sulfonamide derivatives with biological activityArchives of Pharmacal Research, 25
(2002)
Gannett, in Cancer and cancer chemotherapy, eds by A
O. Fathalla, N. Mohamed, W. El‐serwy, Hala Abdelhamid, Sherein El‐Moez, A. Soliman (2013)
Synthesis of some new pyrimidine derivatives and evaluation of their anticancer and antibacterial activitiesResearch on Chemical Intermediates, 39
Hong-Wei Lu, Li‐Ming Zhang, Chao Wang, Ru-fu Chen (2011)
Preparation and properties of new micellar drug carriers based on hydrophobically modified amylopectinCarbohydrate Polymers, 83
J. Parker, J. Stivers (2011)
Dynamics of uracil and 5-fluorouracil in DNA.Biochemistry, 50 5
F. Helaly, A. Khalaf, D. Nashar (2013)
Starch cellulose acetate co-acrylate (SCAA) polymer as a drug carrierResearch on Chemical Intermediates, 39
O. Fathalla, H. Radwan, S. Awad, M. Mohamed (2006)
Synthesis and Biological Evaluation of New Pyrimidine Derivatives.ChemInform, 37
OA Fathalaa, WA Zaghary, HH Radwan, SM Awad, MS Mohamed (2002)
Synthesis of new 2-thiouracil-5-sulfonamide derivatives with biological activity ArchPharm. Res., 25
M. Roussaki, C. Kontogiorgis, D. Hadjipavlou-Litina, S. Hamilakis, A. Detsi (2010)
A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity.Bioorganic & medicinal chemistry letters, 20 13
O. Fathalla, H. Gad, A. Maghaby (2000)
Synthesis of new uracil-5-sulphonamide-p-phenyl derivatives and their effect onBiomphalaria alexandrina snail’s nucleoproteinsArchives of Pharmacal Research, 23
The present work deals with the development of a new slow release polymeric material, based on maize starch/cellulose acetate blend polymerized with acrylic acid monomer by free-radical mechanism. The polymerization was initiated by a redox system. The synthesized polymeric material may be used as a carrier for some active compounds such as anticancer drugs and has been characterized by Fourier transform spectroscopy. The active compounds are a new series of heterocyclic derivatives that had an anticancer effect and were prepared from pyrimidine and coumarin compounds, namely: 7-(2-methoxyphenyl)-5-thioxo-5,6-dihydro[1,2,4]triazolo[4,3-c] pyrimidine-8-carbonitrile (compound I), 8-(2-methoxyphenyl)-3,4-dioxo-6-thioxo-3,4,6,7-tetrahydro-2h-pyrimido[6,1-c]-[1,2,4]triazine-9-carbonitrile (compound II), and 4-substituted-1-(1-(7-methoxy-4-methyl-coumarin-8-yl) ethylidene) thiosemi-carbazide (compound III). They were incorporated into the prepared polymer matrix. The polymer-carried drug was tested for slow release drug delivery through testing it in aqueous media for different time periods and examining it as an anti-proliferative agent against human liver cancer cell line (HEPG2). The release rate of the drug was evaluated in aqueous media at different pHs as well as in dimethyl formamide which is the good solvent of such drugs. The release was measured spectrophotometrically. It was found that the release rate depends on the pH of the aqueous media. The release of the drug in the alkaline media was found to be high compared with other media. Also, the sustained release of the drug was extended to about 20 days. The activity of the released drug against human liver cancer cell line was tested. The results showed that compound (III) gave the highest growth inhibition activity followed by compound (II), while compound (I) indicated the lowest activity against the human liver (HEPG2) cancer cell line.
Research on Chemical Intermediates – Springer Journals
Published: Jan 9, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.