Bevacizumab Reactions 1680, p70 - 2 Dec 2017 Spontaneous nasal septum perforation: case report A 34-year-old woman developed spontaneous nasal septum perforation during treatment with bevacizumab [Avastin; route not stated]. The woman, who had a recurrence of breast cancer with multiple lung metastases, started receiving chemotherapy with bevacizumab 10 mg/kg every two weeks. After receiving four cycles of the chemotherapy, she developed irritation and scabbing in the inferior part of the nasal septum along with occasional blood-streaked discharge. The woman initially received nasal hygiene measures and was kept under observation. After receiving two more cycles of bevacizumab, her symptoms had further increased comprising of epistaxis, nasal congestion and rhinorrhea, which led to recurrent nose blowing. Anterior rhinoscopy and clinical check-up by surgeon showed a perforation involving the anterior portion of the nasal septum. The mucosa was found to be dry with visible masses or other abnormalities in the nasal vestibules [outcome not stated]. Author comment: ’’Nasal bleeding s a common side effect of bevacizumab and is usually mild and intermittent. However, nasal septum perforation is rare’’. "As increasing numbers of patients are receiving bevacizumab, oncologists and head and neck surgeon should be aware of this potential complication.’’ Rodriguez CA, et al. Spontaneous nasal perforation in a bevacizumab-treated patient with metastatic breast cancer. Breast Journal 23: 745-746, No. 6, Nov-Dec 2017. Available from: URL: - Spain 803284712 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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