Bevacizumab Reactions 1680, p68 - 2 Dec 2017 Aggravation of cerebral radiation necrosis: case report In a study, a 53-year-old woman was described who developed aggravation of cerebral radiation necrosis (CRN) following the administration of bevacizumab [route not stated]. The woman with a history of brain metastasis of lung adenocarcinoma was treated with stereotactic radiotherapy. She was diagnosed with CRN in September 2012. From December 2012 to July 2013, she received 10 cycles of bevacizumab. During the treatment, her condition had resolved markedly. Nonetheless, in June 2014, the CRN recurred. From October 2014 to March 2015, she was scheduled to receive seven cycles of bevacizumab 5 mg/kg every three to four weeks. In March 2015, a re-examination demonstrated aggravation of CRN instead of reduction. The woman’s treatment with bevacizumab was discontinued. In September 2015, the CRN exhibited local resolution and dissipation. Author comment: "Long time bevacizumab medications cause blood vessels over trimming, and the CRN aggravation." "The lesion was significantly reduced after discontinuation." Zhuang H, et al. Indication of bevacizumab for cerebral radiation necrosis. Recent Patents on Anti-Cancer Drug Discovery 12: 272-277, No. 3, 2017. Available from: URL: - China 803285422 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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