Eur J Appl Physiol (2017) 117:1907–1915 DOI 10.1007/s00421-017-3679-9 ORIGINAL ARTICLE Beta ‑adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men 1 4 4 2,3 Johan Onslev · Glenn Jacobson · Christian Narkowicz · Vibeke Backer · 1,2 2 1,2 1 Anders Kalsen · Michael Kreiberg · Søren Jessen · Jens Bangsbo · 1,2,3 Morten Hostrup Received: 4 March 2017 / Accepted: 5 July 2017 / Published online: 12 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract association was observed between fat percentage and rac-for- Purpose β -Agonists have been proposed as weight-loss moterol-induced change in energy expenditure. During exer- treatment, because they elevate energy expenditure. How- cise, energy expenditure was not different between treatments, ever, it is unknown what effect β -agonists have on energy although carbohydrate oxidation was 15% higher (P = 0.021) expenditure in overweight individuals. Furthermore, the for rac-formoterol than placebo. Rac-formoterol-induced shift influence of β -agonist R- and S-enantiomer ratio for the in substrate choice from rest to exercise was related to plasma increased energy expenditure is insufficiently explored. ln-rac-formoterol concentrations (r = 0.75, P = 0.005). Methods Nineteen males were included in the study Conclusion Selective β -adrenoceptor agonism effec - of which 14 completed. Subjects were 31.6 (±3.5) years tively increases metabolic rate and
European Journal of Applied Physiology – Springer Journals
Published: Jul 12, 2017
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