J Nutr Health Aging. 2018;22(6):710-717 © Serdi and Springer-Verlag International SAS, part of Springer Nature BERBERINE IMPROVES COGNITIVE DEFICIENCY AND MUSCULAR DYSFUNCTION VIA ACTIVATION OF THE AMPK/SIRT1/PGC-1A PATHWAY IN SKELETAL MUSCLE FROM NATURALLY AGING RATS 1 1 1 1 1 1 2 1 1 1 Y. YU , Y. ZHAO , F. TENG , J. LI , Y. GUAN , J. XU , X. LV , F. GUAN , M. ZHANG , L. CHEN 1. Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China; 2. The Second Hospital, Jilin University, Changchun 130012, China. Corresponding author: Dr. Ming Zhang, Associate Professor, Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, 126 Xin Min Street, Changchun, Jilin 130021, China. E-mail: email@example.com Abstract: Objective: The manifestations of aging include cognitive deficits and muscular dysfunction, which are closely linked to impairment of mitochondrial biogenesis. Berberine, an isoquinoline alkaloid, presents multiple anti-diabetic pharmacological effects. Evidence has indicated that insulin resistance and cognitive impairment share the same pathogenesis, and berberine could reverse glucose metabolism abnormalities and muscle mitochondrial dysfunction induced by a high-fat diet. This study was used to investigate whether berberine could be
The Journal of Nutrition, Health & Aging – Springer Journals
Published: Mar 6, 2018
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