Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the... J Nutr Health Aging. 2018;22(6):710-717 © Serdi and Springer-Verlag International SAS, part of Springer Nature BERBERINE IMPROVES COGNITIVE DEFICIENCY AND MUSCULAR DYSFUNCTION VIA ACTIVATION OF THE AMPK/SIRT1/PGC-1A PATHWAY IN SKELETAL MUSCLE FROM NATURALLY AGING RATS 1 1 1 1 1 1 2 1 1 1 Y. YU , Y. ZHAO , F. TENG , J. LI , Y. GUAN , J. XU , X. LV , F. GUAN , M. ZHANG , L. CHEN 1. Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China; 2. The Second Hospital, Jilin University, Changchun 130012, China. Corresponding author: Dr. Ming Zhang, Associate Professor, Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, 126 Xin Min Street, Changchun, Jilin 130021, China. E-mail: zhangming_00@126.com Abstract: Objective: The manifestations of aging include cognitive deficits and muscular dysfunction, which are closely linked to impairment of mitochondrial biogenesis. Berberine, an isoquinoline alkaloid, presents multiple anti-diabetic pharmacological effects. Evidence has indicated that insulin resistance and cognitive impairment share the same pathogenesis, and berberine could reverse glucose metabolism abnormalities and muscle mitochondrial dysfunction induced by a high-fat diet. This study was used to investigate whether berberine could be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Nutrition, Health & Aging Springer Journals

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats

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Publisher
Springer Paris
Copyright
Copyright © 2018 by Serdi and Springer-Verlag France SAS, part of Springer Nature
Subject
Medicine & Public Health; Geriatrics/Gerontology; Nutrition; Aging; Neurosciences; Primary Care Medicine; Quality of Life Research
ISSN
1279-7707
eISSN
1760-4788
D.O.I.
10.1007/s12603-018-1015-7
Publisher site
See Article on Publisher Site

Abstract

J Nutr Health Aging. 2018;22(6):710-717 © Serdi and Springer-Verlag International SAS, part of Springer Nature BERBERINE IMPROVES COGNITIVE DEFICIENCY AND MUSCULAR DYSFUNCTION VIA ACTIVATION OF THE AMPK/SIRT1/PGC-1A PATHWAY IN SKELETAL MUSCLE FROM NATURALLY AGING RATS 1 1 1 1 1 1 2 1 1 1 Y. YU , Y. ZHAO , F. TENG , J. LI , Y. GUAN , J. XU , X. LV , F. GUAN , M. ZHANG , L. CHEN 1. Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China; 2. The Second Hospital, Jilin University, Changchun 130012, China. Corresponding author: Dr. Ming Zhang, Associate Professor, Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, 126 Xin Min Street, Changchun, Jilin 130021, China. E-mail: zhangming_00@126.com Abstract: Objective: The manifestations of aging include cognitive deficits and muscular dysfunction, which are closely linked to impairment of mitochondrial biogenesis. Berberine, an isoquinoline alkaloid, presents multiple anti-diabetic pharmacological effects. Evidence has indicated that insulin resistance and cognitive impairment share the same pathogenesis, and berberine could reverse glucose metabolism abnormalities and muscle mitochondrial dysfunction induced by a high-fat diet. This study was used to investigate whether berberine could be

Journal

The Journal of Nutrition, Health & AgingSpringer Journals

Published: Mar 6, 2018

References

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