Bedaquiline

Bedaquiline Reactions 1680, p66 - 2 Dec 2017 QT prolongation: 2 case reports In a retrospective observational study, two patients (a woman) [ages not stated; not all sexes stated] were described who developed QT prolongation during treatment bedaquiline [routes, duration of treatment to reaction onset and outcomes not stated]. The patients with drug-resistant tuberculosis were started on treatment with bedaquiline 400mg once daily for 14 days, then 200mg three times a week for 22 weeks. Subsequently, they developed QT prolongation. Later, the woman died [cause of death not stated]. Author comment: "Enthusiasm over bedaquiline and delamanid has been curtailed following concerns of potential cardiotoxicity. Both new drugs are associated with QT prolongation". Borisov SE, et al. Effectiveness and safety of bedaquilinecontaining regimens in the treatment of MDR- and XDR-TB: A multicentre study. European Respiratory Journal 49: 1700387, No. 5, May 2017. Available from: URL: http:// doi.org/10.1183/13993003.00387-2017 - Russia 803284365 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Bedaquiline

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-38997-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p66 - 2 Dec 2017 QT prolongation: 2 case reports In a retrospective observational study, two patients (a woman) [ages not stated; not all sexes stated] were described who developed QT prolongation during treatment bedaquiline [routes, duration of treatment to reaction onset and outcomes not stated]. The patients with drug-resistant tuberculosis were started on treatment with bedaquiline 400mg once daily for 14 days, then 200mg three times a week for 22 weeks. Subsequently, they developed QT prolongation. Later, the woman died [cause of death not stated]. Author comment: "Enthusiasm over bedaquiline and delamanid has been curtailed following concerns of potential cardiotoxicity. Both new drugs are associated with QT prolongation". Borisov SE, et al. Effectiveness and safety of bedaquilinecontaining regimens in the treatment of MDR- and XDR-TB: A multicentre study. European Respiratory Journal 49: 1700387, No. 5, May 2017. Available from: URL: http:// doi.org/10.1183/13993003.00387-2017 - Russia 803284365 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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