Reactions 1680, p66 - 2 Dec 2017 QT prolongation: 2 case reports In a retrospective observational study, two patients (a woman) [ages not stated; not all sexes stated] were described who developed QT prolongation during treatment bedaquiline [routes, duration of treatment to reaction onset and outcomes not stated]. The patients with drug-resistant tuberculosis were started on treatment with bedaquiline 400mg once daily for 14 days, then 200mg three times a week for 22 weeks. Subsequently, they developed QT prolongation. Later, the woman died [cause of death not stated]. Author comment: "Enthusiasm over bedaquiline and delamanid has been curtailed following concerns of potential cardiotoxicity. Both new drugs are associated with QT prolongation". Borisov SE, et al. Effectiveness and safety of bedaquilinecontaining regimens in the treatment of MDR- and XDR-TB: A multicentre study. European Respiratory Journal 49: 1700387, No. 5, May 2017. Available from: URL: http:// doi.org/10.1183/13993003.00387-2017 - Russia 803284365 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera