Clin Drug Investig (2017) 37:845–852 DOI 10.1007/s40261-017-0541-0 ORIGINAL RESEARCH ARTICLE Basal and Bolus Insulin Dose Changes after Switching Basal Insulin to Insulin Degludec in Patients with Type 1 Diabetes Mellitus: A Pilot Study 1,3 1 1 1 • • • • Yoshiyuki Hamamoto Sachiko Honjo Kanta Fujimoto Shinsuke Tokumoto 1,2 1 1 • • Hiroki Ikeda Yoshiharu Wada Hiroyuki Koshiyama Published online: 17 June 2017 Springer International Publishing Switzerland 2017 Abstract switched from once-daily BI (21.7 ± 8.3 to 19.3 ± 8.8 Background and objectives Ultra-long-acting insulin U/day, p = 0.016) especially in the injection before degludec (DEG) has a longer duration of action and less breakfast and evening meal. Body weight and hypo- daily variability relative to other basal insulin (BI), and glycemia frequency was not signiﬁcantly different. thus may beneﬁt patients with type 1 diabetes mellitus Conclusion DEG improved glycemic control when swit- (T1DM). We examined the impact of switching BI to DEG ched from once-daily BI and maintained glycemic control on glycemic control and insulin dose in T1DM. when switched from twice-daily BI without increasing Methods T1DM patients (n = 22; six male; mean age: hypoglycemia. 64.5 ± 12.6 years) receiving basal-bolus insulin therapy were included.
Clinical Drug Investigation – Springer Journals
Published: Jun 17, 2017
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