Avian embryo susceptibility to Italian H7N1 avian influenza viruses belonging to different genetic lineages

Avian embryo susceptibility to Italian H7N1 avian influenza viruses belonging to different... In the present paper we report of the results of an immunohistochemical investigation to assess tissue tropism and viral replication in developing chicken, turkey, Muscovy duck and mallard duck embryos, of Italian H7N1 isolates belonging to different genetic lineages. LPAI isolates were chosen on the basis of the location in the phylogenetic tree: a progenitor strain, A/ty/Italy/977/V99, (exhibiting no additional glycosylation site, nAGS), strain A/ty/Italy/2379/V99 (AGS in position 123) and strain A/ty/Italy/3675/V99 (AGS in position 149) were selected. The latter two strains belonged to distinct lineages originating from the pool of progenitor strains. HPAI isolate A/ty/Italy/4580/V99 was also included in the study. All the embryos tested supported the growth of HPAI. The LPAI isolates replicated readily in the allantoic layer of the CAM of all the species tested, and did not grow in the developing chicken, turkey and Muscovy duck embryos. In contrast, they replicated to different extents in the respiratory tract of the developing mallard embryo, which also presented lower mortality rates than the other species. We conclude from these findings that the pathogenesis of LPAI infections in mallard embryos is different to that observed in other species, and should be investigated further. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Avian embryo susceptibility to Italian H7N1 avian influenza viruses belonging to different genetic lineages

Loading next page...
 
/lp/springer_journal/avian-embryo-susceptibility-to-italian-h7n1-avian-influenza-viruses-2skZPUEKUI
Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-002-0837-z
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial