REVIEW ARTICLE Autonomic innervation of the heart: Role of molecular imaging Myron C. Gerson, MD Division of Cardiology, University of Cincinnati College of Medicine, Cincinnati Received Jun 29, 2015; accepted Jun 29, 2015 doi:10.1007/s12350-015-0236-y Remarkable progress has been made in the diag- of sympathetic and parasympathetic nerve activity on nosis and treatment of cardiac disease in the last the complex origins of ventricular arrhythmias are 50 years, and yet the burden of heart failure is growing explored in terms of cellular and clinical mechanisms. and the challenge of preventing arrhythmic death Sympathetic and parasympathetic nerves differentially remains. The role of the autonomic nervous system in alter cellular effective refractory periods, with sympa- the development and progression of heart failure and in thetic activation shortening refractoriness and enhancing the initiation of sudden cardiac death has been studied the potential for early and heterogeneous depolariza- extensively. Beta-adrenergic blockade has emerged as a tions. Parasympathetic activation prolongs refractoriness cornerstone in the treatment of both heart failure and and increases the potential for other focal pacemakers to cardiac arrhythmias. Nevertheless, the ability to non- take a dominant role. A role of sympathetic innervation invasively measure cardiac autonomic activity, use on up-regulation of nerve
Journal of Nuclear Cardiology – Springer Journals
Published: Jul 10, 2015
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