Autoimmune Sclerosing Cholangitis: a Review of the Overlap between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children

Autoimmune Sclerosing Cholangitis: a Review of the Overlap between Autoimmune Hepatitis and... Curr Hepatology Rep (2017) 16:198–204 DOI 10.1007/s11901-017-0353-y AUTOIMMUNE, CHOLESTATIC, AND BILIARY DISEASES (S GORDON AND C BOWLUS, SECTION EDITORS) Autoimmune Sclerosing Cholangitis: a Review of the Overlap between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children 1 2 1,3 C. Jaramillo & P. L. Valentino & M. Deneau Published online: 11 July 2017 Springer Science+Business Media, LLC 2017 Abstract response to immunosuppression. Rates of liver transplantation Purpose of Review Pediatric patients with autoimmune liver for ASC are identical to those of PSC. disease (ALD) frequently demonstrate clinical, histopatholog- Summary Rather than specifically labeling patients as ASC, ic, cholangiographic, and serologic overlap between primary the most important tasks for clinicians managing ALD are to sclerosing cholangitis and autoimmune hepatitis, termed auto- detect treatable autoimmune lobular inflammation in PSC pa- immune sclerosing cholangitis (ASC). Several large, collabo- tients and to identify cholangiopathy in AIH patients with rative studies have shed light on the epidemiology and natural persistent biochemical abnormalities prior to therapeutic history of ASC in the last 5 years. A detailed genetic and escalation. environmental description of the pathogenesis remains lack- . . ing however. Here, we review recent advancements in knowl- Keywords PSC ASC Primary autoimmune sclerosing edge on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Hepatology Reports Springer Journals

Autoimmune Sclerosing Cholangitis: a Review of the Overlap between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children

Loading next page...
 
/lp/springer_journal/autoimmune-sclerosing-cholangitis-a-review-of-the-overlap-between-3KQnTYJexL
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Hepatology
eISSN
2195-9595
D.O.I.
10.1007/s11901-017-0353-y
Publisher site
See Article on Publisher Site

Abstract

Curr Hepatology Rep (2017) 16:198–204 DOI 10.1007/s11901-017-0353-y AUTOIMMUNE, CHOLESTATIC, AND BILIARY DISEASES (S GORDON AND C BOWLUS, SECTION EDITORS) Autoimmune Sclerosing Cholangitis: a Review of the Overlap between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children 1 2 1,3 C. Jaramillo & P. L. Valentino & M. Deneau Published online: 11 July 2017 Springer Science+Business Media, LLC 2017 Abstract response to immunosuppression. Rates of liver transplantation Purpose of Review Pediatric patients with autoimmune liver for ASC are identical to those of PSC. disease (ALD) frequently demonstrate clinical, histopatholog- Summary Rather than specifically labeling patients as ASC, ic, cholangiographic, and serologic overlap between primary the most important tasks for clinicians managing ALD are to sclerosing cholangitis and autoimmune hepatitis, termed auto- detect treatable autoimmune lobular inflammation in PSC pa- immune sclerosing cholangitis (ASC). Several large, collabo- tients and to identify cholangiopathy in AIH patients with rative studies have shed light on the epidemiology and natural persistent biochemical abnormalities prior to therapeutic history of ASC in the last 5 years. A detailed genetic and escalation. environmental description of the pathogenesis remains lack- . . ing however. Here, we review recent advancements in knowl- Keywords PSC ASC Primary autoimmune sclerosing edge on

Journal

Current Hepatology ReportsSpringer Journals

Published: Jul 11, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off