Curr Diab Rep (2017) 17: 130 https://doi.org/10.1007/s11892-017-0962-4 PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE, SECTION EDITOR) Autoimmune Responses to Exosomes and Candidate Antigens Contribute to Type 1 Diabetes in Non-Obese Diabetic Mice 1,2 3,4 2 3 Yang D. Dai & Huiming Sheng & Peter Dias & M. Jubayer Rahman & 1 1 1 Roman Bashratyan & Danielle Regn & Kristi Marquardt Published online: 28 October 2017 Springer Science+Business Media, LLC 2017 Abstract are homologous to an endogenous murine leukemia retrovi- Purpose of Review The initial autoimmune trigger of type 1 rus. Autoantibodies and autoreactive T cells spontaneously diabetes (T1D) remains unclear. In non-obese diabetic (NOD) developed in NOD mice can react to these retroviral antigens. mice, islet inflammation starts early in life, suggesting the More importantly, expression of the retroviral antigens in the presence of an endogenous trigger for the spontaneous auto- islet mesenchymal stem cells is associated with disease sus- immune response in this T1D mouse model. In this review, we ceptibility, and the expression is restricted to T1D-susceptible argue that abnormal release of exosomes might be the trigger but not resistant mouse strains. of the early inflammatory and autoimmune responses in the Summary Exosomes are novel autoimmune
Current Diabetes Reports – Springer Journals
Published: Oct 28, 2017
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