Journal of Neurology (2018) 265:1469–1471 https://doi.org/10.1007/s00415-018-8912-x LE T TER TO THE EDITORS Autoimmune hepatitis induced by a single injection of interferon-β 1a in a patient with multiple sclerosis 1 1 2 1 Hiroki Yamaguchi · Kenji Sakai · Yoshinori Goto · Masahito Yamada Received: 15 February 2018 / Revised: 18 May 2018 / Accepted: 18 May 2018 / Published online: 29 May 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Sirs, at the spinal cord on T2-weighted images (Fig. 1a, b). The C2–C3 lesion was enhanced using gadolinium. We made a Several multiple sclerosis (MS) patients have presented with diagnosis of MS according to the 2010 Revised McDonald autoimmune hepatitis (AIH) induced by IFN-β1a injections Diagnostic Criteria for MS . He did not fulfill the crite- [1–4]. Here, we describe a patient with MS who developed ria of seronegative neuromyelitis optica spectrum disorders AIH several days after the first injection of a small amount . Intravenous methylprednisolone pulse therapy improved of IFN-β1a. his symptoms. Seven days after the final administration of A 44-year-old man presented with sensory impairment methylprednisolone, injection of IFN-β1a (7.5 µg) (Avonex, in the right lower limb and right trunk between the nipple Biogen) was started; 5 days after the first injection, hepa- and
Journal of Neurology – Springer Journals
Published: May 29, 2018
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