Acta Neurol Belg (2017) 117:775–776 DOI 10.1007/s13760-016-0733-z LETTER TO THE EDITOR Autoimmune cerebellar ataxia with glutamic acid decarboxylase 65 antibodies associated with central vestibular symptoms 1 1 1,2 1,3 • • • • Fre ´de ´ric London Nawal Hadhoum He ´le `ne Ze ´phir Olivier Outteryck 1,4 Patrick Vermersch Received: 8 October 2016 / Accepted: 2 December 2016 / Published online: 17 December 2016 Belgian Neurological Society 2016 Keywords Glutamic acid decarboxylase Autoimmunity Case presentation Central vestibular pathway A 40-year-old man with medical history of insulin-depen- dant type 1 diabetes mellitus (DM1) since 5 years com- Introduction plained in 2014 of subacute onset of mild but constant vertigo increasing with head movements, especially to the The spectrum of neurological syndromes associated with right. He had no hearing loss but reported mild nausea. antibodies to glutamic acid decarboxylase 65 (GAD65-Ab) Clinical examination performed by otolaryngologist includes cerebellar ataxia (CA), stiff-person syndrome, demonstrated harmonious vestibular syndrome since limbic encephalitis, progressive encephalomyelitis, and videonystagmography showed positional nystagmus drift- some refractory epileptic patients . We describe a ing toward the right side, Dix Hallpike test was positive patient presenting with central vestibular symptoms pre- and otolithic evoked potentials showed decreased sacculo-
Acta Neurologica Belgica – Springer Journals
Published: Dec 17, 2016
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