Diabetologia (2017) 60:1834–1835 DOI 10.1007/s00125-017-4376-2 RESEARCH LETTER Autoantibody binding in liquid phase to IL-2 in human sera is not type 1 diabetes specific 1 2 1 3 Ilaria Marzinotto & Daniela Liberati & Cristina Brigatti & Riccardo Bonfanti & 1 1 1,4 1,4 Angela Stabilini & Paolo Monti & Emanuele Bosi & Lorenzo Piemonti & Vito Lampasona Received: 30 May 2017 /Accepted: 13 June 2017 /Published online: 19 July 2017 Springer-Verlag GmbH Germany 2017 . . . . Keywords Autoantibodies Autoimmunity ELISA IL-2 locyte colony-stimulating factor, IL-6, IL-17 and IL-22, have . . Immunoprecipitation LIPS Type 1 diabetes been described in a variety of other diseases, including auto- immune syndromes sometimes presenting together with type 1 diabetes . In an original report by Pérol et al , IL-2 auto- antibodies, measured by a direct ELISA assay, were suggested to be present in the NOD mouse, where they correlated with Abbreviations disease development, and in around 25% of humans at onset of LIPS Luciferase immunoprecipitation system type 1 diabetes. To investigate the presence of IL-2 autoanti- NLuc-IL-2 Recombinant IL-2 tagged with a NanoLuc bodies in human type 1 diabetes, we developed a novel assay luciferase reporter based on the luciferase
Diabetologia – Springer Journals
Published: Jul 19, 2017
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