tential to elucidate the importance of various angiogenic References factors in flap microcirculation and delay, as well as dur- ing normal wound healing. Clinically, this system may 1. Tagliacozzi G (1597) De curtorum chirurgia per in sitionem (icones). Dindoni, Venice provide a useful model for prefabricating flaps by pro- 2. Garcia P, Nieto C, Ortega I (1991) Morphologic changes in the viding a vehicle for ectopic gene expression (i.e., bone vascularisation of delayed flaps in rabbits. Br J Plast Surg morphogenic proteins, etc.). One looks forward to fur- 44:285-290 ther innovative studies from this group, especially the 3. Morris S, Taylor GI (1995) The time sequence of the delay phe- VEGIF work mentioned in their discussion. nomenon: when is surgical delay effective? An experimental study. Plast Reconstr Surg 95(3): 526–533 In short, the present study represents an important 4. Pang et al (1986) Augmentation of blood flow in delayed ran- first step in applying therapeutic angiogenesis and gene dom skin flaps in the pig: effect of length of delay period and therapy to plastic surgical problems. Obviously, much angiogenesis Plast Reconstr Surg 78:68-73 work remains to be done. The intellectual payoff of such 5. Ishiguro et al (1994) Basic
European Journal of Plastic Surgery – Springer Journals
Published: Aug 16, 1999
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