Attachment of bovine parvovirus to O-linked alpha 2,3 neuraminic acid on glycophorin A

Attachment of bovine parvovirus to O-linked alpha 2,3 neuraminic acid on glycophorin A The bovine parvovirus (BPV) hemagglutinates human erythrocytes by binding to glycophorin A (GPA). The purpose of this study was to determine which carbohydrate on GPA binds BPV. Treatment of GPA with α2,3,-6,-8 neuraminidase eliminated binding of BPV to GPA. Beta-elimination of O-linked sialic acids on GPA eliminated binding, while removal of N-linked carbohydrates using the N-glycosidase PNGase F failed to eliminate binding. Treatment of GPA with a neuraminidase which specifically cleaved α2,3 glycosidic bonds eliminated BPV binding and, following this treatment, virus binding to GPA was restored by reconstitution of α2,3-linked neuraminic acids. These results indicated the O-linked α2,3 neuraminic acids of GPA bind BPV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Attachment of bovine parvovirus to O-linked alpha 2,3 neuraminic acid on glycophorin A

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag/Wien
Subject
Biomedicine; Medical Microbiology; Virology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-005-0496-y
Publisher site
See Article on Publisher Site

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