Atropine overdose

Atropine overdose Reactions 1704, p57 - 2 Jun 2018 O S Delirium: case report A 14-year-old girl developed delirium following an overdose of atropine for treatment of organophosphate poisoning. The girl was admitted to the ICU for a suspected organophosphate [EKALUX] consumption. She was diagnosed with organophosphate poisoning. She was kept on nil per oral and gastric lavage was performed. She was administered Ringer Lactate, glucose [dextrose normal saline] followed by IV STAT atropine injection 0.6 mg/ampoule, 20 ampoules and IV atropine injection 30 ampoules along with normal saline. Additionally, she was administered ranitidine and pralidoxime. She was conscious but irritable on the following day. She was administered Ringer’s lactate, dextrose normal saline, pralidoxime-chloride [pralidoxime], ranitidine and IV atropine injection 3 ampoules twice daily. However, she developed delirium and hallucinations accompanied by dilated pupils. The girl’s treatment with atropine was discontinued. There was subsequent control of delirium within 3 hours of atropine discontinuation. The reaction secondary to atropine administration demonstrated atropine overdose and unreasonable disease management. She was transferred to another hospital for further management due to deterioration of her health [time to reaction onset not stated]. Author comment: "[T]he patient developed signs of delirium and hallucinations, with dilations noted in the pupils. The adverse event that followed atropine administration and the consecutive evidence of atropine- induced delirium suggested a remarkable association. . . . subsequent control of delirium within three hours of drug stoppage. The toxic reaction that followed atropine administrations clearly indicates over dosing and an irrational approach of disease management." Moudgil K, et al. Atropine induced delirium in Organophosphate (OP) insecticide poisoning: A case report. Journal of Young Pharmacists 10: 243-245, No. 2, Apr 2018. Available from: URL: http://doi.org/10.5530/jyp.2018.10.54 - India 803322903 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Atropine overdose

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46700-x
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p57 - 2 Jun 2018 O S Delirium: case report A 14-year-old girl developed delirium following an overdose of atropine for treatment of organophosphate poisoning. The girl was admitted to the ICU for a suspected organophosphate [EKALUX] consumption. She was diagnosed with organophosphate poisoning. She was kept on nil per oral and gastric lavage was performed. She was administered Ringer Lactate, glucose [dextrose normal saline] followed by IV STAT atropine injection 0.6 mg/ampoule, 20 ampoules and IV atropine injection 30 ampoules along with normal saline. Additionally, she was administered ranitidine and pralidoxime. She was conscious but irritable on the following day. She was administered Ringer’s lactate, dextrose normal saline, pralidoxime-chloride [pralidoxime], ranitidine and IV atropine injection 3 ampoules twice daily. However, she developed delirium and hallucinations accompanied by dilated pupils. The girl’s treatment with atropine was discontinued. There was subsequent control of delirium within 3 hours of atropine discontinuation. The reaction secondary to atropine administration demonstrated atropine overdose and unreasonable disease management. She was transferred to another hospital for further management due to deterioration of her health [time to reaction onset not stated]. Author comment: "[T]he patient developed signs of delirium and hallucinations, with dilations noted in the pupils. The adverse event that followed atropine administration and the consecutive evidence of atropine- induced delirium suggested a remarkable association. . . . subsequent control of delirium within three hours of drug stoppage. The toxic reaction that followed atropine administrations clearly indicates over dosing and an irrational approach of disease management." Moudgil K, et al. Atropine induced delirium in Organophosphate (OP) insecticide poisoning: A case report. Journal of Young Pharmacists 10: 243-245, No. 2, Apr 2018. Available from: URL: http://doi.org/10.5530/jyp.2018.10.54 - India 803322903 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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