Atorvastatin/fusidic acid interaction

Atorvastatin/fusidic acid interaction Reactions 1704, p56 - 2 Jun 2018 X S Rhabdomyolysis: case report A 51-year-old man developed severe rhabdomyolysis following concomitant administration of fusidic acid for an osteitis and atorvastatin. The man, who was on multiple medications including systemic fusidic acid 500mg three times a day [route not stated] for an osteitis and atorvastatin 80mg once a day [route and indication not stated], experienced leg pain a week after undergoing a stress test and 33 days post the initiation of antibiotic therapy. Fusidic acid was withdrawn. The man was unable to walk due to muscle weakness and myalgia, and he was hospitalised. During hospitalisation, he experienced anuria and exhibited significantly elevated levels of serum creatinine, serum creatine kinase, myoglobin and AST. On the third day of hospitalisation, atorvastatin was suspended. His condition improved after 9 days of hospitalisation and dialysis; however, a sequelar amyotrophy of his thighs was observed. He was discharged without statin treatment. Author comment: "Following a severe case of rhabdomyolysis . . . after a co-administration of atorvastatin and fusidic acid, we describe this interaction". Deljehier T, et al. Rhabdomyolysis after co-administration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions. British Journal of Clinical Pharmacology 84: 1057-1063, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/bcp.13515 - France 803323505 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Atorvastatin/fusidic acid interaction

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46699-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p56 - 2 Jun 2018 X S Rhabdomyolysis: case report A 51-year-old man developed severe rhabdomyolysis following concomitant administration of fusidic acid for an osteitis and atorvastatin. The man, who was on multiple medications including systemic fusidic acid 500mg three times a day [route not stated] for an osteitis and atorvastatin 80mg once a day [route and indication not stated], experienced leg pain a week after undergoing a stress test and 33 days post the initiation of antibiotic therapy. Fusidic acid was withdrawn. The man was unable to walk due to muscle weakness and myalgia, and he was hospitalised. During hospitalisation, he experienced anuria and exhibited significantly elevated levels of serum creatinine, serum creatine kinase, myoglobin and AST. On the third day of hospitalisation, atorvastatin was suspended. His condition improved after 9 days of hospitalisation and dialysis; however, a sequelar amyotrophy of his thighs was observed. He was discharged without statin treatment. Author comment: "Following a severe case of rhabdomyolysis . . . after a co-administration of atorvastatin and fusidic acid, we describe this interaction". Deljehier T, et al. Rhabdomyolysis after co-administration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions. British Journal of Clinical Pharmacology 84: 1057-1063, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/bcp.13515 - France 803323505 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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