Purpose Abnormalities of the solute-linked carrier family 26 member A3 (SLC26A3) are implicated in the pathogenesis of several diseases including ulcerative colitis (UC). The short communication aimed at investigating the associations of UC with SLC26A3 (rs17154444, rs7810937, rs7785539, rs2108225 and rs6951457) polymorphisms and its expression in colonic tissues. Methods The techniques of SNaPshot method, quantitative real-time PCR and immunohistochemical analysis were conducted. Results and conclusion We found that the rs2108225 variation in SLC26A3 might increase the risk of UC and affect its expression at both the mRNA and protein levels in colonic tissues of patients with UC. Moreover, the rs17154444 variation might influence the severity of UC. . . . . Keywords SLC26A3 Ulcerative colitis Polymorphism Haplotype Expression Introduction majority of studies to date have mainly focused on the five common SNPs, namely rs17154444, rs7810937, The abnormal intestinal epithelial ion transport has been rs7785539, rs2108225 and rs6951457. The present study confirmed as a key factor for promoting intestinal secretion aimed to ascertain whether SLC26A3 variations and its ex- andreducingabsorptioninUCpatientswithdiarrhoea. pression in colonic tissues might influence UC susceptibil- + + − In recent years, the coupled operation of Na /H and Cl / ity in the Chinese population. HCO3 exchangers,
International Journal of Colorectal Disease – Springer Journals
Published: May 31, 2018
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