Biochem Genet https://doi.org/10.1007/s10528-018-9867-4 ORIGINAL ARTICLE Association of TNF‑α‑308 Polymorphism with Susceptibility to Autoimmune Hepatitis in Tunisians 1,2 1 1 Marwa Chaouali · Mouna Ben Azaiez · Aymen Tezeghdenti · 1 2 1 Awatef Lagha · Basma Yacoubi‑Oueslati · Ezzeddine Ghazouani · 3 1 Hatem Ben Abdallah · Radhia Kochkar Received: 13 June 2017 / Accepted: 23 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiol- ogy and several proinflammatory cytokines are implicated in its pathogenesis. The association of TNF-α gene polymorphism with AIH onset is not fully elucidated especially in the Tunisian population. The aim of this study was to determine the association of TNF-α (-308 G > A) polymorphism with AIH susceptibility and with TNF-α expression or clinical manifestations of AIH. A total of 50 AIH patients and 150 controls were included. Evaluation of TNF-α polymorphism was performed by ARMS PCR method. A significantly higher frequence of the AA genotype was found in AIH patients compared to controls (34 vs. 8%, p = 0.00002, OR 5.88). The frequency of the A-allele was significantly higher in patients with AIH compared to controls (55 vs. 37.3%, p = 0.002, OR 2.05). The G-allele was significantly more frequent in healthy controls
Biochemical Genetics – Springer Journals
Published: May 29, 2018
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