Association of T-786C polymorphism of endothelial nitric oxide synthase 3 gene with the functional state of the myocardium in patients with ischemic heart disease combined with type 2 diabetes mellitus

Association of T-786C polymorphism of endothelial nitric oxide synthase 3 gene with the... The association of polymorphism T-786C of the endothelial NO-synthase gene NOS3 with the functional state of the left ventricle (LV) was studied among residents of the West Siberian region with ischemic heart disease (IHD), including that combined with diabetes mellitus type 2 (DMT2). Carriers of genotype–786TT had the greatest ejection fraction of the left ventricle in the group of patients without DMT2 (p = 0.012). This dependence was not revealed in the group of patients with IHD combined with DMT2. In the group with genotype–786TC, the frequency of left ventricular hypertrophy was higher among patients with DMT2 than patients without it (p = 0.025). There was no association between NOS3T–786C polymorphism and the severity of functional class of heart failure in both the groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Association of T-786C polymorphism of endothelial nitric oxide synthase 3 gene with the functional state of the myocardium in patients with ischemic heart disease combined with type 2 diabetes mellitus

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795417060102
Publisher site
See Article on Publisher Site

Abstract

The association of polymorphism T-786C of the endothelial NO-synthase gene NOS3 with the functional state of the left ventricle (LV) was studied among residents of the West Siberian region with ischemic heart disease (IHD), including that combined with diabetes mellitus type 2 (DMT2). Carriers of genotype–786TT had the greatest ejection fraction of the left ventricle in the group of patients without DMT2 (p = 0.012). This dependence was not revealed in the group of patients with IHD combined with DMT2. In the group with genotype–786TC, the frequency of left ventricular hypertrophy was higher among patients with DMT2 than patients without it (p = 0.025). There was no association between NOS3T–786C polymorphism and the severity of functional class of heart failure in both the groups.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jul 12, 2017

References

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