Int Ophthalmol (2018) 38:1135–1146 https://doi.org/10.1007/s10792-017-0574-7 ORIGINAL PAPER Association of Single Nucleotide Polymorphisms in XRCC1 (194) and XPD (751) with Age-related cataract . . . . . Tafheem Khosa Sana Aslam Saima Mustafa Atif Akbar Rehan Sadiq Shaikh Furhan Iqbal Received: 12 December 2016 / Accepted: 20 May 2017 / Published online: 30 May 2017 Springer Science+Business Media Dordrecht 2017 Abstract individually or in various combinations with the Purpose Age-related cataract (ARC) is a multifacto- studied epidemiological factors known to be associ- rial disease and different risk factors, including genetic ated with ARC. and environmental, are responsible for the development Results Our results indicated that both SNPs of its various types. The aim of this study was to find out Arg194Trp in XRCC1 (P = 0.967) and Lys751Gln a correlation, if any, between ARC and the single in XPD (P = 0.995) were not associated with ARC nucleotide polymorphisms (SNPs) in DNA repair genes whether they were analyzed individually or in com- XRCC1 (X-ray repair cross-complementary-1) bined form (P [ 0.05). Analysis of epidemiological [Arg194Trp (rs1799782)] and XPD (xerodermapig- factors revealed that age (P \ 0.001), cast of subjects mentosa complementation group D) [Lys751Gln (P = 0.001), diabetes (P\ 0.001),
International Ophthalmology – Springer Journals
Published: May 30, 2017
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