Association of Polymorphic markers D6S2414 and D6S1271 located in the MHC locus (6p21.31) with chronic glomerulonephritis in the Russian population of Moscow

Association of Polymorphic markers D6S2414 and D6S1271 located in the MHC locus (6p21.31) with... The distributions of the alleles and genotypes of Polymorphic markers D6S2414 and D6S1271 located among class II MHC genes have been studied in patients with chronic glomerulonephritis (CGN) and healthy donors. Both markers have been found to be associated with the disease. Since these microsatellites are located in the chromosomal region occupied by class II MHC genes, their association with CGN indirectly indicates that class II MHC genes are involved in the development of this pathology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Association of Polymorphic markers D6S2414 and D6S1271 located in the MHC locus (6p21.31) with chronic glomerulonephritis in the Russian population of Moscow

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Publisher
Springer Journals
Copyright
Copyright © 2006 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Microbial Genetics and Genomics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795406120155
Publisher site
See Article on Publisher Site

Abstract

The distributions of the alleles and genotypes of Polymorphic markers D6S2414 and D6S1271 located among class II MHC genes have been studied in patients with chronic glomerulonephritis (CGN) and healthy donors. Both markers have been found to be associated with the disease. Since these microsatellites are located in the chromosomal region occupied by class II MHC genes, their association with CGN indirectly indicates that class II MHC genes are involved in the development of this pathology.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Dec 17, 2006

References

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