Association of major histocompatibility complex-class II-DR in Egyptian patients with basal cell carcinoma

Association of major histocompatibility complex-class II-DR in Egyptian patients with basal cell... Basal and squamous cell carcinomas are the most common skin cancers, accounting for about 70% of all skin malignancies. They are almost always found on sun-exposed areas such as the head and neck and are common in fair-skinned individuals. The aim of this research is to detect any associations, which could be found between basal cell carcinoma (BCC) and different HLA-DRB1 alleles. We analyzed 45 randomized Egyptian patients with BCC aged from 19–79 years and 157 Egyptian healthy persons as controls. Categorical and quantitative data were compared. We found that DRB1-01 and DRB1-07 tend to confer a risk of BCC. Their odd ratios (OR) were 9.07 and 5.3, and the confidence intervals (CI) were 3.66–22.5, and 2.55–10.9, respectively. DRB1-15 and DRB1-11 showed a tendency to protect from BCC (OR = 0.14 and 0.13, and CI = 0.033–0.608 and 0.026–0.704, respectively). Our results presented further evidence of an association between HLA-DRB1 and BCC. Larger studies are required to reveal the complex associations between HLA alleles and development of skin cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Association of major histocompatibility complex-class II-DR in Egyptian patients with basal cell carcinoma

Loading next page...
 
/lp/springer_journal/association-of-major-histocompatibility-complex-class-ii-dr-in-lw8lEpM1GP
Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-010-0423-7
Publisher site
See Article on Publisher Site

Abstract

Basal and squamous cell carcinomas are the most common skin cancers, accounting for about 70% of all skin malignancies. They are almost always found on sun-exposed areas such as the head and neck and are common in fair-skinned individuals. The aim of this research is to detect any associations, which could be found between basal cell carcinoma (BCC) and different HLA-DRB1 alleles. We analyzed 45 randomized Egyptian patients with BCC aged from 19–79 years and 157 Egyptian healthy persons as controls. Categorical and quantitative data were compared. We found that DRB1-01 and DRB1-07 tend to confer a risk of BCC. Their odd ratios (OR) were 9.07 and 5.3, and the confidence intervals (CI) were 3.66–22.5, and 2.55–10.9, respectively. DRB1-15 and DRB1-11 showed a tendency to protect from BCC (OR = 0.14 and 0.13, and CI = 0.033–0.608 and 0.026–0.704, respectively). Our results presented further evidence of an association between HLA-DRB1 and BCC. Larger studies are required to reveal the complex associations between HLA alleles and development of skin cancer.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Oct 1, 2010

References

  • The HLA dictionary 1999: a summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens
    Schreuder, G; Hurley, C; Marsh, S; Lau, M; Maiers, M; Kollman, C; Noreen, H

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off