Basal and squamous cell carcinomas are the most common skin cancers, accounting for about 70% of all skin malignancies. They are almost always found on sun-exposed areas such as the head and neck and are common in fair-skinned individuals. The aim of this research is to detect any associations, which could be found between basal cell carcinoma (BCC) and different HLA-DRB1 alleles. We analyzed 45 randomized Egyptian patients with BCC aged from 19–79 years and 157 Egyptian healthy persons as controls. Categorical and quantitative data were compared. We found that DRB1-01 and DRB1-07 tend to confer a risk of BCC. Their odd ratios (OR) were 9.07 and 5.3, and the confidence intervals (CI) were 3.66–22.5, and 2.55–10.9, respectively. DRB1-15 and DRB1-11 showed a tendency to protect from BCC (OR = 0.14 and 0.13, and CI = 0.033–0.608 and 0.026–0.704, respectively). Our results presented further evidence of an association between HLA-DRB1 and BCC. Larger studies are required to reveal the complex associations between HLA alleles and development of skin cancer.
European Journal of Plastic Surgery – Springer Journals
Published: Oct 1, 2010
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