Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection: a Japanese cross-sectional study

Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C... Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B ( IL28B ) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “ IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio (OR) 9.39; 95 % confidence interval (CI), 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 % CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex ( P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection: a Japanese cross-sectional study

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2703-9
Publisher site
See Article on Publisher Site

Abstract

Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B ( IL28B ) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “ IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio (OR) 9.39; 95 % confidence interval (CI), 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 % CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex ( P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2016

References

  • Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    Mohd Hanafiah, K; Groeger, J; Flaxman, AD; Wiersma, ST
  • Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection
    Hayashi, J; Kishihara, Y; Yamaji, K; Furusyo, N; Yamamoto, T; Pae, Y
  • The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection
    Grebely, J; Page, K; Sacks-Davis, R; Loeff, MS; Rice, TM; Bruneau, J
  • Host genomics and HCV treatment response
    Clark, PJ; Thompson, AJ
  • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    Thomas, DL; Thio, CL; Martin, MP; Qi, Y; Ge, D; O’Huigin, C
  • A population-based epidemiology survey of human parvovirus B19 infection: a project of the Kyushu and Okinawa Population Study (KOPS)
    Ihara, T; Furusyo, N; Hayashi, T; Toyoda, K; Murata, M; Hayashi, J

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