Association of (192) Q>R polymorphism of the paraoxonase gene with a lipid profile and components of lipid peroxidation and antioxidant protection in populations of Russians and Buryats from Eastern Siberia

Association of (192) Q>R polymorphism of the paraoxonase gene with a lipid profile and components... The distribution of genotypes and alleles of Q192R polymorphism of the paraoxonase1 (rs622) gene was studied in Russian and Buryat populations living in Eastern Siberia. Correlations between genotypes and some parameters of the lipid profile and lipid peroxidation indicators were revealed. In the group of Russians, the frequency of genotypes was QQ—0.354; QR—0.569 and RR—0.077, alleles Q—0.638, and R—0.362. In the group of Buryats, the genotype frequencies were QQ—0.204; QR—0.629 and RR—0.167, alleles Q—0.518, and R—0.482. No differences in allele and genotype frequencies were established between the groups of Russians and Buryats. In the group of Russians, the VLDL cholesterol content (H = 6.461; p = 0.0395) and diene conjugates (H = 8.107; p = 0.0174) was higher in carriers of genotype QQ than in carriers of genotype RR. In the group of Buryats, the HDL cholesterol content (H = 1.548; p = 0.0461) was higher in carriers of genotype QQ, wherein the concentration of malondialdehyde (H = 13.854, p = 0.0010) was lower in comparison with carriers of genotype RR. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Association of (192) Q>R polymorphism of the paraoxonase gene with a lipid profile and components of lipid peroxidation and antioxidant protection in populations of Russians and Buryats from Eastern Siberia

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S102279541502009X
Publisher site
See Article on Publisher Site

Abstract

The distribution of genotypes and alleles of Q192R polymorphism of the paraoxonase1 (rs622) gene was studied in Russian and Buryat populations living in Eastern Siberia. Correlations between genotypes and some parameters of the lipid profile and lipid peroxidation indicators were revealed. In the group of Russians, the frequency of genotypes was QQ—0.354; QR—0.569 and RR—0.077, alleles Q—0.638, and R—0.362. In the group of Buryats, the genotype frequencies were QQ—0.204; QR—0.629 and RR—0.167, alleles Q—0.518, and R—0.482. No differences in allele and genotype frequencies were established between the groups of Russians and Buryats. In the group of Russians, the VLDL cholesterol content (H = 6.461; p = 0.0395) and diene conjugates (H = 8.107; p = 0.0174) was higher in carriers of genotype QQ than in carriers of genotype RR. In the group of Buryats, the HDL cholesterol content (H = 1.548; p = 0.0461) was higher in carriers of genotype QQ, wherein the concentration of malondialdehyde (H = 13.854, p = 0.0010) was lower in comparison with carriers of genotype RR.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 6, 2015

References

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