Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous psychoses

Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous... Tryptophan hydroxylase is one of the key enzymes involved in serotonergic metabolism. In many studies, an association between the TpH gene and human mentality, as well as mental disorders was demonstrated. This study was designed to analyze the association between three TpH gene polymorphisms (A218C, T3792A, and (CT) n (CA) n (CT) n ) and endogenous psychoses. The patients included into investigation were represented by those with manic-depressive psychosis (93 individuals) and those with the schizophrenia spectrum disorders (307 individuals). An association between the A218C polymorphism with the disorders of the schizophrenia spectrum was demonstrated. These findings confirmed the data obtained earlier for other populations. In addition, an association between the (CT) n (CA) n (CT) n microsatellite repeats and bipolar disease was shown for the first time. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous psychoses

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2009 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795409120114
Publisher site
See Article on Publisher Site

Abstract

Tryptophan hydroxylase is one of the key enzymes involved in serotonergic metabolism. In many studies, an association between the TpH gene and human mentality, as well as mental disorders was demonstrated. This study was designed to analyze the association between three TpH gene polymorphisms (A218C, T3792A, and (CT) n (CA) n (CT) n ) and endogenous psychoses. The patients included into investigation were represented by those with manic-depressive psychosis (93 individuals) and those with the schizophrenia spectrum disorders (307 individuals). An association between the A218C polymorphism with the disorders of the schizophrenia spectrum was demonstrated. These findings confirmed the data obtained earlier for other populations. In addition, an association between the (CT) n (CA) n (CT) n microsatellite repeats and bipolar disease was shown for the first time.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Dec 12, 2009

References

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