Association between sleep disorders and the presence of breast cancer metastases in gynecological practices in Germany: a case–control study of 11,412 women

Association between sleep disorders and the presence of breast cancer metastases in gynecological... Purpose The goal of the present study was to analyze the impact of sleep disorders on the development of metastases in women with breast cancer followed in gynecological practices in Germany. Methods The study included women who were initially diagnosed with breast cancer in 262 gynecological practices in Germany between January 2000 and December 2015 (index date). Participants were followed for up to 5 years. Women diagnosed with breast cancer metastases within a period of 6 months and before the end of follow-up were matched (1:1) by age, index year, physician, type of hormonal therapy (tamoxifen or aromatase inhibitors) and follow-up time (in months) with women without metastases. Regression analyses were conducted to study the association between sleep disorders and the presence of metastases, and these regression analyses were adjusted for depression. Results A total of 11,412 women were included in the present study. The mean age was 59.8 years (SD 11.4 years) and most participants were between 61 and 70 years old (metastases group: 32.6%; no-metastases group: 32.3%). Sleep disorders were associated with a significant increase in the presence of breast cancer metastases in the overall population (odds ratio [OR] 1.31) and in the different age subgroups (ORs between 1.24 and 1.43). Conclusion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

Association between sleep disorders and the presence of breast cancer metastases in gynecological practices in Germany: a case–control study of 11,412 women

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-018-4831-x
Publisher site
See Article on Publisher Site

Abstract

Purpose The goal of the present study was to analyze the impact of sleep disorders on the development of metastases in women with breast cancer followed in gynecological practices in Germany. Methods The study included women who were initially diagnosed with breast cancer in 262 gynecological practices in Germany between January 2000 and December 2015 (index date). Participants were followed for up to 5 years. Women diagnosed with breast cancer metastases within a period of 6 months and before the end of follow-up were matched (1:1) by age, index year, physician, type of hormonal therapy (tamoxifen or aromatase inhibitors) and follow-up time (in months) with women without metastases. Regression analyses were conducted to study the association between sleep disorders and the presence of metastases, and these regression analyses were adjusted for depression. Results A total of 11,412 women were included in the present study. The mean age was 59.8 years (SD 11.4 years) and most participants were between 61 and 70 years old (metastases group: 32.6%; no-metastases group: 32.3%). Sleep disorders were associated with a significant increase in the presence of breast cancer metastases in the overall population (odds ratio [OR] 1.31) and in the different age subgroups (ORs between 1.24 and 1.43). Conclusion

Journal

Breast Cancer Research and TreatmentSpringer Journals

Published: May 29, 2018

References

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