Association between regular thyroxin use and thyroid cancer

Association between regular thyroxin use and thyroid cancer Reactions 1664, p8 - 12 Aug 2017 Association between regular thyroxin use and thyroid cancer There seems to be an association between the regular use of thyroxin in patients with primary hypothyroidism and the development of thyroid cancer, according to study results reported in the Journal of Clinical Pharmacology, although "additional studies are needed to further evaluate and validate these finding". The study retrieved data from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The 1285 patients diagnosed with new-onset thyroid cancer in 2001–2013 were matched with 3855 controls without thyroid cancer. A prior hypothyroidism diagnosis was present in 37 cases (2.88%) and 33 controls (0.86%). In conditional regression analysis, cases were more likely to have hypothyroidism than controls (adjusted odds ratio [OR] 3.01; 95% CI 1.85, 4.89; p<0.001). In patients with hypothyroidism, there was a significant association with thyroid cancer in those who had received continuous thyroxin prescriptions for ≥60 days within 6 months of cancer diagnosis (OR 8.68; 4.34, 17.34; p<0.001) but not in those who were irregular thyroxin users (OR 0.32; 0.09, 1.10). "Although the true role of thyroxin in thyroid cancer development remains to be investigated," note the authors, "physicians might consider this association when treating patients with subclinical hypothyroidism". Hung S-H, et al. Thyroxin Use Is Associated With Increased Risk of Thyroid Cancer in Patients With Hypothyroidism. Journal of Clinical Pharmacology : 19 Jul 2017. Available from: URL: http://doi.org/10.1002/jcph.972 803263076 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Association between regular thyroxin use and thyroid cancer

Reactions Weekly , Volume 1664 (1) – Aug 12, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-34288-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1664, p8 - 12 Aug 2017 Association between regular thyroxin use and thyroid cancer There seems to be an association between the regular use of thyroxin in patients with primary hypothyroidism and the development of thyroid cancer, according to study results reported in the Journal of Clinical Pharmacology, although "additional studies are needed to further evaluate and validate these finding". The study retrieved data from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The 1285 patients diagnosed with new-onset thyroid cancer in 2001–2013 were matched with 3855 controls without thyroid cancer. A prior hypothyroidism diagnosis was present in 37 cases (2.88%) and 33 controls (0.86%). In conditional regression analysis, cases were more likely to have hypothyroidism than controls (adjusted odds ratio [OR] 3.01; 95% CI 1.85, 4.89; p<0.001). In patients with hypothyroidism, there was a significant association with thyroid cancer in those who had received continuous thyroxin prescriptions for ≥60 days within 6 months of cancer diagnosis (OR 8.68; 4.34, 17.34; p<0.001) but not in those who were irregular thyroxin users (OR 0.32; 0.09, 1.10). "Although the true role of thyroxin in thyroid cancer development remains to be investigated," note the authors, "physicians might consider this association when treating patients with subclinical hypothyroidism". Hung S-H, et al. Thyroxin Use Is Associated With Increased Risk of Thyroid Cancer in Patients With Hypothyroidism. Journal of Clinical Pharmacology : 19 Jul 2017. Available from: URL: http://doi.org/10.1002/jcph.972 803263076 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664

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Reactions WeeklySpringer Journals

Published: Aug 12, 2017

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