Association between radioactive fallout from 1951–1962 US nuclear tests at the Nevada Test Site and cancer mortality in midwestern US populations

Association between radioactive fallout from 1951–1962 US nuclear tests at the Nevada Test Site... We determined the association between radionuclide deposition levels from nuclear testing at the Nevada Test Site (NTS) and cancer mortality rates in 513 counties of the Midwestern states of Iowa, Illinois, Kansas, Missouri, and Nebraska. The 10-day cumulative deposition for 54 radionuclides and 1-year cumulative deposition for 19 radionuclides were determined with isotope ratios based on each test and 131I levels in the 513 counties obtained from the US National Cancer Institute’s 131I fallout study. Deposition calculations were done for each test and each radionuclide. Age-adjusted cancer mortality rates for 84 organ-gender combinations for the periods 1950–1959, 1960–1969, 1970–1979, and 1979–1995 were used. Analyses included permutation-based randomization tests for Spearman rank correlation (adjusted for multiple testing). Age-adjusted cancer mortality rates for connective and soft tissue sarcoma, thymus, and female lymphosarcoma and cancer of the colon, brain, thyroid, and uterus were significantly correlated with total fallout and total precipitation during 1951–1957 and 1962. 187W had the highest cumulative deposition density at 10 days postshot (2783 MBq/m2) among the NTS radionuclides considered. The most significant correlations were observed for 10-day cumulative deposition density of 181W, 185W, 54Mn, 187W, 24Na, 185W, 199Au, 7Be, 60Co, and deposition density of 185W, 54Mn, 7Be, and 60Co present at 1-year with mortality for cancers such as female connective and soft tissue sarcoma, male and female thymus, female colon, male and female thyroid, female brain, male multiple myeloma, female breast, and uterine cancer. Significant correlations included isotopic forms of mutagenic metals such as antimony, beryllium, cadmium, cobalt, cesium, manganese, rhodium, selenium, tellurium, and tungsten. The large number of significant correlation tests beyond expectation warrants deeper questions related to the toxicology of fission products and induced radionuclides, validity of kriging procedures, and new studies on core sampling of watersheds and trees in regions assumed to receive the greatest levels of environmental radiocontamination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Ecology Springer Journals

Association between radioactive fallout from 1951–1962 US nuclear tests at the Nevada Test Site and cancer mortality in midwestern US populations

Loading next page...
 
/lp/springer_journal/association-between-radioactive-fallout-from-1951-1962-us-nuclear-FwJa2tygBA
Publisher
Springer Journals
Copyright
Copyright © 2008 by MAIK Nauka
Subject
Life Sciences; Environment, general; Ecology
ISSN
1067-4136
eISSN
1608-3334
D.O.I.
10.1134/S1067413608070060
Publisher site
See Article on Publisher Site

Abstract

We determined the association between radionuclide deposition levels from nuclear testing at the Nevada Test Site (NTS) and cancer mortality rates in 513 counties of the Midwestern states of Iowa, Illinois, Kansas, Missouri, and Nebraska. The 10-day cumulative deposition for 54 radionuclides and 1-year cumulative deposition for 19 radionuclides were determined with isotope ratios based on each test and 131I levels in the 513 counties obtained from the US National Cancer Institute’s 131I fallout study. Deposition calculations were done for each test and each radionuclide. Age-adjusted cancer mortality rates for 84 organ-gender combinations for the periods 1950–1959, 1960–1969, 1970–1979, and 1979–1995 were used. Analyses included permutation-based randomization tests for Spearman rank correlation (adjusted for multiple testing). Age-adjusted cancer mortality rates for connective and soft tissue sarcoma, thymus, and female lymphosarcoma and cancer of the colon, brain, thyroid, and uterus were significantly correlated with total fallout and total precipitation during 1951–1957 and 1962. 187W had the highest cumulative deposition density at 10 days postshot (2783 MBq/m2) among the NTS radionuclides considered. The most significant correlations were observed for 10-day cumulative deposition density of 181W, 185W, 54Mn, 187W, 24Na, 185W, 199Au, 7Be, 60Co, and deposition density of 185W, 54Mn, 7Be, and 60Co present at 1-year with mortality for cancers such as female connective and soft tissue sarcoma, male and female thymus, female colon, male and female thyroid, female brain, male multiple myeloma, female breast, and uterine cancer. Significant correlations included isotopic forms of mutagenic metals such as antimony, beryllium, cadmium, cobalt, cesium, manganese, rhodium, selenium, tellurium, and tungsten. The large number of significant correlation tests beyond expectation warrants deeper questions related to the toxicology of fission products and induced radionuclides, validity of kriging procedures, and new studies on core sampling of watersheds and trees in regions assumed to receive the greatest levels of environmental radiocontamination.

Journal

Russian Journal of EcologySpringer Journals

Published: Nov 26, 2008

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off