Association between high activity of DNA polymerase iota and the development of human uveal melanoma

Association between high activity of DNA polymerase iota and the development of human uveal melanoma Enzymatic activity of DNA polymerase iota (Pol ι) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol ι activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol ι oncogenic potential. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Association between high activity of DNA polymerase iota and the development of human uveal melanoma

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Publisher
Nauka/Interperiodica
Copyright
Copyright © 2006 by Pleiades Publishing, Inc.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795406010121
Publisher site
See Article on Publisher Site

Abstract

Enzymatic activity of DNA polymerase iota (Pol ι) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol ι activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol ι oncogenic potential.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 1, 2006

References

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