Arch Gynecol Obstet (2017) 296:551–558 DOI 10.1007/s00404-017-4443-4 GY NEC O LOG I C O NCO L OG Y Association between ERCC2 rs13181 polymorphism and ovarian cancer risk: an updated meta-analysis with 4024 subjects 1 1 2 2 2 3 • • • • • JieNa Li Lei Pan Xia Qin HongYan Chu HuiYing Mu GuoXing Wan Received: 13 December 2016 / Accepted: 22 June 2017 / Published online: 4 July 2017 Springer-Verlag GmbH Germany 2017 Abstract of the variant with increased risk of ovarian cancer after Background Genetic variants in the excision repair cross- excluding the individual study not in agreement with HWE. complimentary group 2 (ERCC2) gene may affect indi- Conclusion The present study suggests that the ERCC2 vidual susceptibility to cancer by modulating the capability gene rs13181 polymorphism might be associated with of DNA damage repair. However, the current studies increased risk of ovarian cancer. concerning the association of ERCC2 rs13181 polymor- phism with ovarian cancer risk provided inconsistent Keywords ERCC2 Polymorphism Ovarian cancer evidence. Meta-analysis Risk Methods This study was to quantitatively summarize the evidence from the individual studies electronically retrieved by a meta-analysis. Introduction Results Totally, nine eligible case–control studies with 1333
Archives of Gynecology and Obstetrics – Springer Journals
Published: Jul 4, 2017
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