Association between allopurinol use and Parkinson’s disease in older adults

Association between allopurinol use and Parkinson’s disease in older adults Introduction Little evidence is available about the association between allopurinol use and Parkinson’s disease. The present study aimed to explore the association between allopurinol use and Parkinson’s disease in older adults in Taiwan. Methods We conducted a population-based case–control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65 years with newly diagnosed Parkinson’s disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65 years without Parkinson’s disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as sub - jects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson’s disease. Results The OR of Parkinson’s disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use. Conclusions No association can be detected between allopurinol use and Parkinson’s disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Geriatric Medicine Springer Journals

Association between allopurinol use and Parkinson’s disease in older adults

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by European Geriatric Medicine Society
Subject
Medicine & Public Health; Geriatrics/Gerontology; Internal Medicine
eISSN
1878-7657
D.O.I.
10.1007/s41999-018-0055-1
Publisher site
See Article on Publisher Site

Abstract

Introduction Little evidence is available about the association between allopurinol use and Parkinson’s disease. The present study aimed to explore the association between allopurinol use and Parkinson’s disease in older adults in Taiwan. Methods We conducted a population-based case–control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65 years with newly diagnosed Parkinson’s disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65 years without Parkinson’s disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as sub - jects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson’s disease. Results The OR of Parkinson’s disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use. Conclusions No association can be detected between allopurinol use and Parkinson’s disease

Journal

European Geriatric MedicineSpringer Journals

Published: Apr 9, 2018

References

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