Assessment of Health Effects of Exogenous Urea: Summary and Key Findings

Assessment of Health Effects of Exogenous Urea: Summary and Key Findings Purpose of Review Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea. Here, we summarize and update key findings on potential health effects of exogenous urea, including carcinogenicity. Recent Findings No definitive target organs for oral exposure were identified; however, results in animal studies suggest that the liver and kidney could be potential target organs of urea toxicity. The available human-subject literature suggests that the impact on lung function is minimal. Based on the literature on exogenous urea, we concluded that there was inadequate information to assess the carcinogenic potential of urea, or perform a quantitative assessment to derive reference values. Summary Given the limited information on exogenous urea, additional research to address gaps for exogenous urea should include long-term cancer bioassays, two-generation reproductive toxicity studies, and mode-of-action investigations. . . . . . Keywords Integrated Risk Information System IRIS Urea Human health assessment Cancer assessment Health effects Introduction from ammonia (NH ), a deamination product of amino acids. Approximately 20–35 g of urea is excreted in human urine per Urea, also known as carbamide, is an endogenous product http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Environmental Health Reports Springer Journals

Assessment of Health Effects of Exogenous Urea: Summary and Key Findings

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply
Subject
Biomedicine; Pharmacology/Toxicology; Medicine/Public Health, general; Environmental Health
eISSN
2196-5412
D.O.I.
10.1007/s40572-018-0198-8
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea. Here, we summarize and update key findings on potential health effects of exogenous urea, including carcinogenicity. Recent Findings No definitive target organs for oral exposure were identified; however, results in animal studies suggest that the liver and kidney could be potential target organs of urea toxicity. The available human-subject literature suggests that the impact on lung function is minimal. Based on the literature on exogenous urea, we concluded that there was inadequate information to assess the carcinogenic potential of urea, or perform a quantitative assessment to derive reference values. Summary Given the limited information on exogenous urea, additional research to address gaps for exogenous urea should include long-term cancer bioassays, two-generation reproductive toxicity studies, and mode-of-action investigations. . . . . . Keywords Integrated Risk Information System IRIS Urea Human health assessment Cancer assessment Health effects Introduction from ammonia (NH ), a deamination product of amino acids. Approximately 20–35 g of urea is excreted in human urine per Urea, also known as carbamide, is an endogenous product

Journal

Current Environmental Health ReportsSpringer Journals

Published: May 1, 2018

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