Assessment of anti-arthritic potential of ethanolic extract and its fractions of aerial parts of Alhagi pseudalhagi (Bieb.) Desv. in animal models

Assessment of anti-arthritic potential of ethanolic extract and its fractions of aerial parts of... The plant Alhagi pseudalhagi (Bieb.) Desv. (family: Fabaceae) have long been used traditionally mainly for the treating rheumatism and gout in Indian system of medicine. The present work explores the phytochemical screening and effect of the crude extract of the aerial parts of A. pseudalhagi and its fractions in different experimental models of arthritis. The dried pulverized aerial parts of the plant were extracted using 95% ethanol and water. The 95% ethanolic extract (APEE) was frac- tionated in four fractions including chloroform fraction (APC), ethyl acetate fraction (APEA), methanolic fraction (APM) and aqueous fraction (APA). Both extracts and all the four fractions were subjected to preliminary phytochemical screening and TLC. Hematological and biochemical parameters viz. measurement of paw volume, joint diameter, body weight, RBC, WBC, Platelets, CRP, RF, Hb, ALT, AST, ALP and Total protein were determined on APEE and APEA and justified by histopathological and radiological analysis. The anti-arthritic activity was evaluated using Formaldehyde induced arthritic model, Turpentine induced arthritic model and complete freund’s adjuvant arthritic model in wistar albino rats. The plant exhibited dose dependent anti arthritic effect in Formaldehyde, Turpentine induced and complete freund’s adjuvant arthritic model. The ethyl acetate fraction showed more significant effect as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oriental Pharmacy and Experimental Medicine Springer Journals

Assessment of anti-arthritic potential of ethanolic extract and its fractions of aerial parts of Alhagi pseudalhagi (Bieb.) Desv. in animal models

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media B.V., part of Springer Nature
Subject
Biomedicine; Biomedicine, general; Pharmacy
ISSN
1598-2386
eISSN
2211-1069
D.O.I.
10.1007/s13596-018-0319-9
Publisher site
See Article on Publisher Site

Abstract

The plant Alhagi pseudalhagi (Bieb.) Desv. (family: Fabaceae) have long been used traditionally mainly for the treating rheumatism and gout in Indian system of medicine. The present work explores the phytochemical screening and effect of the crude extract of the aerial parts of A. pseudalhagi and its fractions in different experimental models of arthritis. The dried pulverized aerial parts of the plant were extracted using 95% ethanol and water. The 95% ethanolic extract (APEE) was frac- tionated in four fractions including chloroform fraction (APC), ethyl acetate fraction (APEA), methanolic fraction (APM) and aqueous fraction (APA). Both extracts and all the four fractions were subjected to preliminary phytochemical screening and TLC. Hematological and biochemical parameters viz. measurement of paw volume, joint diameter, body weight, RBC, WBC, Platelets, CRP, RF, Hb, ALT, AST, ALP and Total protein were determined on APEE and APEA and justified by histopathological and radiological analysis. The anti-arthritic activity was evaluated using Formaldehyde induced arthritic model, Turpentine induced arthritic model and complete freund’s adjuvant arthritic model in wistar albino rats. The plant exhibited dose dependent anti arthritic effect in Formaldehyde, Turpentine induced and complete freund’s adjuvant arthritic model. The ethyl acetate fraction showed more significant effect as

Journal

Oriental Pharmacy and Experimental MedicineSpringer Journals

Published: Jun 4, 2018

References

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