Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T

Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using... Magn Reson Mater Phy (2018) 31:367–374 https://doi.org/10.1007/s10334-017-0658-4 RESEARCH ARTICLE Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T 1 1 2 2 Florian Siedek  · Thorsten Persigehl  · Roman‑Ulrich Mueller  · Volker Burst  · 2 1 1 Thomas Benzing  · David Maintz  · Stefan Haneder   Received: 10 June 2017 / Revised: 28 September 2017 / Accepted: 2 October 2017 / Published online: 23 October 2017 © ESMRMB 2017 Abstract Results Following intervention, mean R2* values sig- Objective Acute kidney injury (AKI) is an important risk nificantly decreased in the RIPC group in both the cortex factor for a number of adverse outcomes including end- (18.6 ± 2.3 vs. 17.5 ± 1.7 Hz; p = 0.0047) and medulla stage renal disease and cardiovascular morbidity and mor- (34 ± 5.2 vs. 32.2 ± 4.2 Hz; p = 0.0001). However, no sig- tality. Whilst many clinical situations that can induce AKI nificant differences were observed in the control group. are known—e.g. drug toxicity, contrast agent exposure or Conclusion RIPC can be non-invasively assessed in ischemia during surgery—targeted preventive or therapeu- healthy volunteers using BOLD MRI at 3T, demonstrating a tic measures are still lacking. As to renoprotective strate- higher oxygen content in kidney tissue. This study presents a gies, remote ischemic preconditioning (RIPC) is one of the first-in-man trial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Magnetic Resonance Materials in Physics, Biology and Medicine Springer Journals

Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by ESMRMB
Subject
Medicine & Public Health; Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics
ISSN
0968-5243
eISSN
1352-8661
D.O.I.
10.1007/s10334-017-0658-4
Publisher site
See Article on Publisher Site

Abstract

Magn Reson Mater Phy (2018) 31:367–374 https://doi.org/10.1007/s10334-017-0658-4 RESEARCH ARTICLE Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T 1 1 2 2 Florian Siedek  · Thorsten Persigehl  · Roman‑Ulrich Mueller  · Volker Burst  · 2 1 1 Thomas Benzing  · David Maintz  · Stefan Haneder   Received: 10 June 2017 / Revised: 28 September 2017 / Accepted: 2 October 2017 / Published online: 23 October 2017 © ESMRMB 2017 Abstract Results Following intervention, mean R2* values sig- Objective Acute kidney injury (AKI) is an important risk nificantly decreased in the RIPC group in both the cortex factor for a number of adverse outcomes including end- (18.6 ± 2.3 vs. 17.5 ± 1.7 Hz; p = 0.0047) and medulla stage renal disease and cardiovascular morbidity and mor- (34 ± 5.2 vs. 32.2 ± 4.2 Hz; p = 0.0001). However, no sig- tality. Whilst many clinical situations that can induce AKI nificant differences were observed in the control group. are known—e.g. drug toxicity, contrast agent exposure or Conclusion RIPC can be non-invasively assessed in ischemia during surgery—targeted preventive or therapeu- healthy volunteers using BOLD MRI at 3T, demonstrating a tic measures are still lacking. As to renoprotective strate- higher oxygen content in kidney tissue. This study presents a gies, remote ischemic preconditioning (RIPC) is one of the first-in-man trial

Journal

Magnetic Resonance Materials in Physics, Biology and MedicineSpringer Journals

Published: Oct 23, 2017

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