Magn Reson Mater Phy (2018) 31:367–374 https://doi.org/10.1007/s10334-017-0658-4 RESEARCH ARTICLE Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T 1 1 2 2 Florian Siedek · Thorsten Persigehl · Roman‑Ulrich Mueller · Volker Burst · 2 1 1 Thomas Benzing · David Maintz · Stefan Haneder Received: 10 June 2017 / Revised: 28 September 2017 / Accepted: 2 October 2017 / Published online: 23 October 2017 © ESMRMB 2017 Abstract Results Following intervention, mean R2* values sig- Objective Acute kidney injury (AKI) is an important risk nificantly decreased in the RIPC group in both the cortex factor for a number of adverse outcomes including end- (18.6 ± 2.3 vs. 17.5 ± 1.7 Hz; p = 0.0047) and medulla stage renal disease and cardiovascular morbidity and mor- (34 ± 5.2 vs. 32.2 ± 4.2 Hz; p = 0.0001). However, no sig- tality. Whilst many clinical situations that can induce AKI nificant differences were observed in the control group. are known—e.g. drug toxicity, contrast agent exposure or Conclusion RIPC can be non-invasively assessed in ischemia during surgery—targeted preventive or therapeu- healthy volunteers using BOLD MRI at 3T, demonstrating a tic measures are still lacking. As to renoprotective strate- higher oxygen content in kidney tissue. This study presents a gies, remote ischemic preconditioning (RIPC) is one of the first-in-man trial
Magnetic Resonance Materials in Physics, Biology and Medicine – Springer Journals
Published: Oct 23, 2017
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