Reactions 1680, p58 - 2 Dec 2017 Epistaxis and gastrointestinal bleeding: 3 case report In a single centre retrospective study of 16 patients, three patients (two men and one woman), aged between 55-85 years were described, who developed epistaxis (two patients) during treatment with aspirin and clopidogrel and gastrointestinal bleeding (one patient) during treatment with warfarin [route, dosage and duration of treatment to reaction onset not stated]. A 76-year-old man, who had a history of factor XI deficiency (FXID) with FXI coagulant activity of 7%, received chronic treatment with aspirin and clopidogrel for coronary artery disease with stents. He developed epistaxis and subsequently therapy with clopidogrel was discontinued. A 55-year-old man, who had a history of factor XI deficiency (FXID) with FXI coagulant activity of 31%, received six months treatment with warfarin for portal vein thrombosis. He developed gastrointestinal bleeding and subsequently therapy with warfarin was discontinued. An 85-year-old woman, who had a history of factor XI deficiency (FXID) with FXI coagulant activity of 1%, received chronic treatment with aspirin and clopidogrel for acute coronary syndrome prophylaxis. She developed epistaxis and subsequently therapy with clopidogrel was discontinued. Author comment: "Four patients with factor XI deficiency had bleeding related to anticoagulants (warfarin)/antiplatelet (clopidogrel, aspirin) agent exposure, two with partial and two with severe deficiency." Chapin J, et al. The safety of chronic antithrombotic therapy in patients with factor XI deficiency. British Journal of Haematology 179: 506-508, No. 3, Nov 2017. Available from: URL: http://doi.org/10.1111/bjh.14227 - USA 803284487 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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