Arterial input function in a dedicated slice for cerebral perfusion measurements in humans

Arterial input function in a dedicated slice for cerebral perfusion measurements in humans Object We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting. Materials and methods Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were opti- mized for the blood signal (short echo time, background suppression, magnitude and phase images). Phase-based evaluation of the signal in the carotid arteries is used to obtain quantitative arterial input functions. Results In all pilot measurements, quantitative arterial input functions were obtained. The resulting absolute perfusion parameters agree well with literature values (gray and white matter mean values of 46 and 24 mL/100 g/min, respectively, for cerebral blood flow and 3.0% and 1.6%, respectively, for cerebral blood volume). Conclusions The proposed method has the potential to quantify arterial input functions in the carotid arteries from a direct measurement without any additional normalization. Keywords Arterial input function · Perfusion imaging · Bolus tracking · Dynamic susceptibility contrast Introduction injected paramagnetic tracer; (4) compatibility with routine clinical DSC-MRI. Although the arterial input function (AIF) is a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Magnetic Resonance Materials in Physics, Biology and Medicine Springer Journals

Arterial input function in a dedicated slice for cerebral perfusion measurements in humans

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Publisher
Springer Journals
Copyright
Copyright © 2017 by ESMRMB
Subject
Medicine & Public Health; Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics
ISSN
0968-5243
eISSN
1352-8661
D.O.I.
10.1007/s10334-017-0663-7
Publisher site
See Article on Publisher Site

Abstract

Object We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting. Materials and methods Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were opti- mized for the blood signal (short echo time, background suppression, magnitude and phase images). Phase-based evaluation of the signal in the carotid arteries is used to obtain quantitative arterial input functions. Results In all pilot measurements, quantitative arterial input functions were obtained. The resulting absolute perfusion parameters agree well with literature values (gray and white matter mean values of 46 and 24 mL/100 g/min, respectively, for cerebral blood flow and 3.0% and 1.6%, respectively, for cerebral blood volume). Conclusions The proposed method has the potential to quantify arterial input functions in the carotid arteries from a direct measurement without any additional normalization. Keywords Arterial input function · Perfusion imaging · Bolus tracking · Dynamic susceptibility contrast Introduction injected paramagnetic tracer; (4) compatibility with routine clinical DSC-MRI. Although the arterial input function (AIF) is a

Journal

Magnetic Resonance Materials in Physics, Biology and MedicineSpringer Journals

Published: Dec 9, 2017

References

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