Artemether/lumefantrine

Artemether/lumefantrine Reactions 1704, p51 - 2 Jun 2018 Drug eruption: case report A 48-year-old woman developed drug eruption following treatment with artemether/lumefantrine [Riamet] for malaria [routes and time to reaction onset not stated]. The woman presented with a five-day history of annular hyperpigmented plaques along with intense pruritus and peripheral vesiculation on the trunk extended to the lower limbs. Five days prior to the presentation, she was diagnosed with malaria and started receiving treatment with artemether 20mg/lumefantrine 120mg for over 60 hours. A histology demonstrated a severe eosinophilic vesicular spongiotic eruption, secondary to the drug. The woman was treated with an optimised topical therapy, after which an improvement was observed over 72 hours. Author comment: "Excepting a bullous eruption reported to the FDA in 2012, which is not documented in the literature, this is the first dermatological complication from [artemether/lumefantrine] aside from generalised pruritus or urticarial rash." "Histology showed severe eosinophilic vesicular spongiotic eruption, likely secondary to a drug." Hishon M, et al. Case report: "Cluster of jewels" drug eruption to malarial treatment Riamet (artemether/lumefantrine). Australasian Journal of Dermatology 59 (Suppl. 1): 69-70, May 2018. Available from: URL: http://doi.org/10.1111/ ajd.17_12815 [abstract] - Australia 803323564 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Artemether/lumefantrine

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46694-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p51 - 2 Jun 2018 Drug eruption: case report A 48-year-old woman developed drug eruption following treatment with artemether/lumefantrine [Riamet] for malaria [routes and time to reaction onset not stated]. The woman presented with a five-day history of annular hyperpigmented plaques along with intense pruritus and peripheral vesiculation on the trunk extended to the lower limbs. Five days prior to the presentation, she was diagnosed with malaria and started receiving treatment with artemether 20mg/lumefantrine 120mg for over 60 hours. A histology demonstrated a severe eosinophilic vesicular spongiotic eruption, secondary to the drug. The woman was treated with an optimised topical therapy, after which an improvement was observed over 72 hours. Author comment: "Excepting a bullous eruption reported to the FDA in 2012, which is not documented in the literature, this is the first dermatological complication from [artemether/lumefantrine] aside from generalised pruritus or urticarial rash." "Histology showed severe eosinophilic vesicular spongiotic eruption, likely secondary to a drug." Hishon M, et al. Case report: "Cluster of jewels" drug eruption to malarial treatment Riamet (artemether/lumefantrine). Australasian Journal of Dermatology 59 (Suppl. 1): 69-70, May 2018. Available from: URL: http://doi.org/10.1111/ ajd.17_12815 [abstract] - Australia 803323564 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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